5H-吡咯并[2,3-b]吡嗪-2-羧酸甲酯 | 1363381-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡嗪类
• 中文名称: 5H-吡咯并[2,3-b]吡嗪-2-羧酸甲酯
• 英文名称: Methyl 5H-pyrrolo[2,3-B]pyrazine-2-carboxylate
• 英文别名: methyl 5H-pyrrolo[2,3-b]pyrazine-2-carboxylate
• CAS: 1363381-89-8
• 化学式: C₈H₇N₃O₂
• 分子量: 177.16
• InChiKey: LKYVYGGBGJSMJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Heteroaryl-substituted triazoles as APJ receptor agonists
  申请人：AMGEN INC.

  公开号：US11046680B1

  公开（公告）日：2021-06-29

  Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

  式（I）和式（II）化合物、其药学上可接受的盐、前述任何化合物的立体异构体或其混合物是 APJ 受体的激动剂，可用于治疗心血管疾病和其他疾病。式 I 和式 II 的化合物具有如下结构： 其中变量的定义在本文中提供。
• HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS
  申请人：Amgen Inc.

  公开号：EP3541805B1

  公开（公告）日：2020-10-14
• SUBSTITUTED INDOLE MCL-1 INHIBITORS
  申请人：Vanderbilt University

  公开号：US20210283138A1

  公开（公告）日：2021-09-16

  The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.