2,4-二氯苯甲酸酐 | 51417-52-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4-二氯苯甲酸酐
• 英文名称: 2,4-dichlorobenzoic anhydride
• 英文别名: (2,4-Dichlorobenzoyl) 2,4-dichlorobenzoate
• CAS: 51417-52-8
• 化学式: C₁₄H₆Cl₄O₃
• 分子量: 364.012
• InChiKey: MEIRCVABHWFXDR-UHFFFAOYSA-N

物化性质

• 沸点：
  499.0±45.0 °C(Predicted)
• 密度：
  1.551±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-二氯苯甲酸酐 在 氯化亚砜 作用下， 以 苯 为溶剂， 生成 N-(2,4-二氯苯甲酰基)-2-吡咯烷酮
  参考文献：
  名称：

  Ermakov, A. I.; Pleshkova, A. P.; Sorokin, A. A., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, # 9, p. 1819 - 1825

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氯苯甲酸 在 吡啶 、 五氯化磷 作用下， 生成 2,4-二氯苯甲酸酐
  参考文献：
  名称：

  Intramolecular aromatic and aliphatic Ullmann reactions

  摘要：

  DOI：

  10.1021/jo00928a024

文献信息

• Visible light-induced transformation of aldehydes to esters, carboxylic anhydrides and amides
  作者：Silvia Gaspa、Inês Raposo、Leonor Pereira、Gabriele Mulas、Pier Carlo Ricci、Andrea Porcheddu、Lidia De Luca

  DOI：10.1039/c9nj01984g

  日期：——

  A transition metal- and organophotocatalyst free synthesis of esters, carboxylic anhydrides and amides from aldehydes induced by visible-light has been reported. The proposed methodology can be carried out by the use of sunlight or artificial visible light as a blue LED source. The methodology has a very broad applicability and the desired products are obtained in very satisfactory yields.

  已经报道了由可见光诱导的从醛类到酯类，羧酸酐和酰胺类的无过渡金属和有机光催化剂的合成。可以通过使用阳光或人造可见光作为蓝色LED光源来执行所提出的方法。该方法具有非常广泛的适用性，并且以非常令人满意的产率获得了所需的产物。
• ZnCl₂‐Mediated Synthesis of Carboxylic Anhydrides using 2‐Acyl‐4,5‐dichloropyridazin‐3(2<i>H</i>)‐ones
  作者：Yong‐Dae Park、Jeum‐Jong Kim、Ho‐Kyun Kim、Su‐Dong Cho、Young‐Jin Kang、Ki Hun Park、Sang‐Gyeong Lee、Yong‐Jin Yoon

  DOI：10.1081/scc-200048939

  日期：2005.1.1

  Abstract ZnCl2 is an efficient catalyst for synthesis of carboxylic acid anhydride from 2‐acyl‐4,5‐dichloropyridazin‐3(2H)‐ones. Treatment of 2‐acyl‐4,5‐dichloropyridazin‐3(2H) ‐ones with ZnCl2 (0.5 equivalents) and air in refluxing dry THF or acetonitrile gave the corresponding symmetric acid anhydrides in good to excellent yield.

  摘要 ZnCl2 是由 2-酰基-4,5-二氯哒嗪-3(2H)-酮合成羧酸酐的有效催化剂。在回流干燥 THF 或乙腈中，用 ZnCl2（0.5 当量）和空气处理 2-酰基-4,5-二氯哒嗪-3(2H)-酮，得到相应的对称酸酐，收率良好至极好。
• L-ODDC PRODRUGS FOR CANCER
  申请人：Chu David C.K.

  公开号：US20100266674A1

  公开（公告）日：2010-10-21

  The main drawback in the use of most nucleoside anticancer agents originates from their hydrophilic nature, of which property requires a high and frequent dosage for an intravenous administration. Unlike other nucleoside anti-tumor agents, troxacitabine appears to predominantly enter tumor cells by passive diffusion rather then by using nucleoside transporters, although this may be model dependent. Accordingly, in the present work, a small library of twenty troxacitabine prodrugs has been synthesized using a parallel approach in order to evaluate the relationship between the lipophilicity of the prodrugs and their antitumor activity. Biological evaluation of the prodrugs on two non-small cell lung cancer cell lines (A549 and SW1573) and in pancreatic cell lines clearly showed better antitumor activity than that of troxacitabine, with IC 50 values in the nanomolar range.

  大多数核苷类抗癌药物的主要缺点源于它们亲水性的特性，这种特性需要高剂量和频繁的静脉注射。与其他核苷类抗肿瘤药物不同，托沙他滨似乎主要通过被动扩散进入肿瘤细胞，而不是使用核苷转运体，尽管这可能是模型相关的。因此，在本研究中，使用并行方法合成了二十种托沙他滨前药库，以评估前药的亲脂性与其抗肿瘤活性之间的关系。对两种非小细胞肺癌细胞系（A549和SW1573）和胰腺细胞系的前药进行生物评价，明显显示出比托沙他滨更好的抗肿瘤活性，IC50值在纳摩尔范围内。
• Mulls containing chain structure clay suspension aids
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0034387A2

  公开（公告）日：1981-08-26

  A liquid mull is provided having improved physical stability, consisting of a liquid phase, comprising a major proportion of a nonionic surfactant and optionally a minor proportion of a nonaqueous solvent, and a dispersed solid phase comprising a particulate material which is insoluble in the liquid phase of the mull. From 1 % to 15% by weight of the composition of a chain structure type clay is included to aid the physical stability of the mull, so that insoluble particulate materials such as builders having ordinary particle sizes may also be incorporated. Preferred compositions are substantially anhydrous to allowthe optional inclusion of water sensi. tive detergency adjuvants such as enzymes or bleaches. The compositions may optionally contain up to 25% of a further dispersion aid selected from anionic surfactants, cationic surfactants, zwitterionic surfactants and hydrotropic materials. Such mulls have utility, for example, as detergent compositions.

  本发明提供了一种具有更好物理稳定性的液体闷闷不乐剂，它由液相和分散固相组成，液相主要由非离子表面活性剂和少量非水溶剂组成，分散固相由不溶于闷闷不乐剂液相的颗粒材料组成。按重量计，在组合物中加入 1%至 15%的链状结构粘土，以提高泥浆的物理稳定性，这样也可以加入不溶于泥浆的颗粒材料，如具有普通粒度的建筑材料。优选的组合物基本上是无水的，这样就可以选择性地加入对水敏感的去污佐剂，如酶或漂白剂。组合物还可以选择性地含有高达 25% 的其它分散助剂，这些助剂选自阴离子表面活性剂、阳离子表面活性剂、齐聚亚铵盐表面活性剂和亲水材料。例如，这种混合物可用作洗涤剂组合物。
• Roechling,H.; Hoerlein,G., Justus Liebigs Annalen der Chemie, 1974, p. 504 - 522
  作者：Roechling,H.、Hoerlein,G.

  DOI：——

  日期：——