5-氯-2,3,4-三氟苯甲酰氟化物 | 101513-69-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氯-2,3,4-三氟苯甲酰氟化物
• 英文名称: 5-chloro-2,3,4-trifluoro-benzoyl fluoride
• 英文别名: 2,3,4-trifluoro-5-chlorobenzoyl fluoride；2,3,4-trifluoro-5-chlorobenzoylfluoride；5-Chloro-2,3,4-trifluorobenzoyl fluoride
• CAS: 101513-69-3
• 化学式: C₇HClF₄O
• 分子量: 212.531
• InChiKey: HDPODBQAFOAFJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-氯-2,3,4-三氟苯甲酰氟化物 生成 5-氯-2,3,4-三氟苯甲酸
  参考文献：
  名称：

  KLAUKE, E.;PETERSEN, U.;GROHE, K.

  摘要：

  DOI：

文献信息

• 2,3,4,5-tetrahalogenobenzene derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05072038A1

  公开（公告）日：1991-12-10

  2,3,4,5-trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO, R.sup.1 is H, Cl or F, and R.sup.2 is Cl or F, it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.

  公式为##STR1##的2,3,4,5-三卤苯衍生物，其中R为--COOH，--COCl，--COF，--CN，--CONH.sub.2，--CH.sub.2 OH，--CH.sub.2 Cl，--CHCl.sub.2，--CCl.sub.3或--CHO，R.sup.1为H，Cl或F，R.sup.2为Cl或F，只有R.sup.1或R.sup.2可能是F，并且从苯腈与氟化钾反应开始制备它们的过程。这些新化合物是喹诺酮羧酸等抗菌剂的中间体。
• 2,4,5-Trihalogeno- and 2,3,4,5-tetrahalogenobenzene derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05200548A1

  公开（公告）日：1993-04-06

  2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO, R.sup.1 is H, Cl or F, and R.sup.2 is Cl or F, it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone caboxylic acids.

  化学式为##STR1##的2,4,5-三卤代苯衍生物，其中R为--COOH，--COCl，--COF，--CN，--CONH.sub.2，--CH.sub.2 OH，--CH.sub.2 Cl，--CHCl.sub.2，--CCl.sub.3或--CHO，R.sup.1为H，Cl或F，R.sup.2为Cl或F，仅当R.sup.1或R.sup.2为F时，其制备过程起始于苯甲腈与氟化钾反应。这些新化合物是类似喹诺酸类抗菌剂的中间体。
• 8-chloro-1-cyclopropyl-6,7-difluoro-1,
  申请人：Bayer Aktiengesellschaft

  公开号：US05468861A1

  公开（公告）日：1995-11-21

  The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxy lic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

  本发明涉及公式（I）的7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧基-3-喹诺酸类化合物，其中X1，X2，R1和R2的含义如下所述。此外，本发明还涉及制备公式（I）化合物的方法以及含有它们的抗菌剂。
• 2,4,5-trihalogeno- and 2,3,4,5-tetrahalogenobenzene derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US05530158A1

  公开（公告）日：1996-06-25

  2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO, R.sup.1 is H, Cl or F, and R.sup.2 is Cl or F, it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.

  该文中提到的公式为##STR1##，其中R为--COOH、--COCl、--COF、--CN、--CONH.sub.2、--CH.sub.2 OH、--CH.sub.2 Cl、--CHCl.sub.2、--CCl.sub.3或--CHO，R.sup.1为H、Cl或F，R.sup.2为Cl或F，仅R.sup.1或R.sup.2可能为F。该文还介绍了从苯甲腈与氟化钾反应开始制备这些新化合物的过程。这些新化合物是抗菌剂如喹诺酸类的中间体。
• 7-amino-1-cyclopropyl-6,8-dihalogeno-
  申请人：Bayer Aktiengesellschaft

  公开号：US05571812A1

  公开（公告）日：1996-11-05

  The invention is related to 7-amino-1-cyclopropyl-6,8- dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

  该发明涉及式(I)的7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧基-3-喹啉羧酸，其中X.sup.1，X.sup.2，R.sup.1和R.sup.2的含义如下所述。此外，该发明涉及制备式(I)化合物的过程以及含有它们的抗菌剂。