2-{6-[3(R)-amino-piperidin-1-yl]-5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{6-[3(R)-amino-piperidin-1-yl]-5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile
• 英文别名: 2-[[6-[(3R)-3-aminopiperidin-1-yl]-5-chloro-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile
• 化学式: C₁₇H₁₈ClN₅O₂
• 分子量: 359.815
• InChiKey: QWCRMWNCTSFODM-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  阿格列汀 在 盐酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 2-{6-[3(R)-amino-piperidin-1-yl]-5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile
  参考文献：
  名称：

  Dipeptidyl peptidase inhibitors

  摘要：

  公开号：

  EP1586571B3

文献信息

• DIPEPTIDYL PEPTIDASE INHIBITORS
  申请人：Feng Jun

  公开号：US20090275750A1

  公开（公告）日：2009-11-05

  Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.

  制备公式（I）化合物的方法，其中变量如本文所述定义。另外，还提供了用于制备可能用于抑制二肽基肽酶的化合物的方法。
• [EN] DIPEPTIDYL PEPTIDASE INHIBITORS<br/>[FR] INHIBITEURS DE LA DIPEPTIDYLE PEPTIDASE
  申请人：SYRRX INC

  公开号：WO2005095381A1

  公开（公告）日：2005-10-13

  Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising Formula (I): ##STR1## wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C=NR9; and each R1, R2, R3, R4 and R9 are as defined herein.

  提供了与DPP-IV和其他S9蛋白酶一起使用的化合物、药物、试剂盒和方法，其中包括具有式（I）的化合物：##STR1##其中M为N或CR4；Q1和Q2分别独立地选自CO、SO、SO2和C=NR9的群组；每个R1、R2、R3、R4和R9如本文所定义。
• THERAPEUTIC AGENT FOR DIABETES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1970063A1

  公开（公告）日：2008-09-17

  The present invention relates to an agent for pancreas protection which contains a combination of a blood glucose lowering drug that does not stimulate insulin secretion and a compound represented by the formula (I) wherein each symbol is defined as in the description, or a salt thereof, or a compound represented by the formula (II) wherein each symbol is defined as in the description, or a salt thereof.

  本发明涉及一种保护胰腺的制剂，它包含一种不刺激胰岛素分泌的降血糖药物和一种由式（I）表示的化合物的组合物 其中各符号的定义见说明，或其盐，或由式（II）代表的化合物 其中每个符号的定义见说明、 或其盐。
• PROCESS FOR THE PREPARATION OF PYRIMIDINEDIONE DERIVATIVES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1924567A2

  公开（公告）日：2008-05-28
• Therapeutic Agent for Diabetes
  申请人：Takeuchi Koji

  公开号：US20090042863A1

  公开（公告）日：2009-02-12

  The present invention relates to an agent for pancreas protection which contains a combination of a blood glucose lowering drug that does not stimulate insulin secretion and a compound represented by the formula (I) wherein each symbol is defined as in the description, or a salt thereof, or a compound represented by the formula (II) wherein each symbol is defined as in the description, or a salt thereof.