(E)-(2-chlorobenzylidene)hydrazine | 1019918-68-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-(2-chlorobenzylidene)hydrazine
• 英文别名: (2-chlorobenzylidene)hydrazine；(E)-1-(2-chlorobenzylidene)hydrazine；(E)-(2-chlorophenyl)methylidenehydrazine
• CAS: 1019918-68-3
• 化学式: C₇H₇ClN₂
• 分子量: 154.599
• InChiKey: IZKCWJUTZCUYDW-BJMVGYQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-(2-chlorobenzylidene)hydrazine 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 chloramine T trihydrate 、 potassium carbonate 作用下， 以 2-甲基四氢呋喃 、 甲苯 为溶剂， 反应 2.0h， 生成 7-chloro-3-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine
  参考文献：
  名称：

  Palladium-Catalyzed Triazolopyridine Synthesis: Synthesis of 7-Chloro-3-(2-Chlorophenyl)-1,2,4-Triazolo[4,3-a]Pyridine

  摘要：

  Chloramine-T is thermally unstable and heating of chloramines-T beyond the temperature disclosed in this procedure should not be conducted without further safety evaluation. Hydrazine should be handled in a fume hood as it is an animal carcinogen and has been identified it as a potential human carcinogen. In addition, anhydrous hydrazine is potentially explosive, especially in contact with metals, and should only be handled as its hydrate.

  DOI：

  10.15227/orgsyn.090.0287
• 作为产物：
  描述：

  2-氯苯甲醛 在 hydrazine hydrate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 (E)-(2-chlorobenzylidene)hydrazine
  参考文献：
  名称：

  Palladium-Catalyzed Triazolopyridine Synthesis: Synthesis of 7-Chloro-3-(2-Chlorophenyl)-1,2,4-Triazolo[4,3-a]Pyridine

  摘要：

  Chloramine-T is thermally unstable and heating of chloramines-T beyond the temperature disclosed in this procedure should not be conducted without further safety evaluation. Hydrazine should be handled in a fume hood as it is an animal carcinogen and has been identified it as a potential human carcinogen. In addition, anhydrous hydrazine is potentially explosive, especially in contact with metals, and should only be handled as its hydrate.

  DOI：

  10.15227/orgsyn.090.0287

文献信息

• Palladium-Catalyzed Coupling of Aldehyde-Derived Hydrazones: Practical Synthesis of Triazolopyridines and Related Heterocycles
  作者：Oliver R. Thiel、Michal M. Achmatowicz、Andreas Reichelt、Robert D. Larsen

  DOI：10.1002/anie.201001999

  日期：2010.11.2

  The palladium‐catalyzed intermolecular coupling of aldehyde‐derived hydrazones with chloroazines, followed by oxidative cyclization under mild conditions afforded access to a broad variety of bicyclic heterocyclic scaffolds (see scheme) that have potential for use in drug discovery.

  钯催化的醛衍生的azo酮与氯嗪的分子间偶联，然后在温和的条件下进行氧化环化，可以使用各种各样的双环杂环骨架（参见方案），这些骨架可能会用于药物发现。
• [EN] METHOD OF TREATING CANCER WITH A COMBINATION OF BENZYLIDENEGUANIDINE DERIVATIVES AND CHEMOTHERAPEUTIC AGENT.<br/>[FR] PROCÉDÉ DE TRAITEMENT DE CANCER AVEC UNE COMBINAISON DE DÉRIVÉS DE BENZYLIDÈNEGUANIDINE ET D'AGENT CHIMIOTHÉRAPEUTIQUE
  申请人：INFLECTIS BIOSCIENCE

  公开号：WO2017021216A1

  公开（公告）日：2017-02-09

  The present invention relates to a composition for use in treating a glioma or ameliorating the effects of a glioma, particularly glioblastoma, wherein said composition comprises a first active agent selected from the group consisting of a compound of formula (I), or a pharmaceutically acceptable salt thereof, (I) and a second active agent, which is temozolomide, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

  本发明涉及一种用于治疗胶质瘤或改善胶质瘤效果，特别是胶质母细胞瘤的组合物，所述组合物包括选自以下化合物组的第一活性剂，即化合物(I)或其药学上可接受的盐(I)，以及第二活性剂，即替莫唑胺或其药学上可接受的盐；以及一种药学上可接受的载体。
• Imidazo- and triazolo-pyridine compounds and methods of use thereof
  申请人：Zhang Dawei

  公开号：US20080161303A1

  公开（公告）日：2008-07-03

  The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, B, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

  本发明涉及一类新的化合物，用于预防和治疗与蛋白激酶介导的疾病有关的疾病，包括炎症和相关病症。这些化合物具有通用的I式，其中A、B、R1、R2、R3和R4在此处被定义。该发明还涵盖包括I式中的一个或多个化合物的制药组合物，以及用于治疗P38地图激酶介导的疾病，包括类风湿性关节炎、牛皮癣和其他炎症性疾病的化合物和组合物的用途，以及用于制备I式化合物的中间体和工艺。
• Method of treating cancer with a combination of benzylideneguanidine derivatives and chemotherapeutic agent
  申请人：InFlectis BioScience

  公开号：US10675257B2

  公开（公告）日：2020-06-09

  The present invention relates to a composition for use in treating a glioma or ameliorating the effects of a glioma, particularly glioblastoma, wherein said composition comprises a first active agent selected from the group consisting of a compound of formula (I), or a pharmaceutically acceptable salt thereof, (I) and a second active agent, which is temozolomide, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

  本发明涉及一种用于治疗胶质瘤或改善胶质瘤（尤其是胶质母细胞瘤）影响的组合物，其中所述组合物包含选自由式（I）化合物或其药学上可接受的盐、（I）和第二活性剂（即替莫唑胺或其药学上可接受的盐）组成的组中的第一活性剂；以及药学上可接受的载体。
• 10.1007/s11696-024-03551-x
  作者：Falakshahi, Maryam、Mahmoodi, Nosrat O.、Khalili, Behzad、Melal, Sarah Poormoradkhan

  DOI：10.1007/s11696-024-03551-x

  日期：——

  etc. The synthesis of acetazolamide from the corresponding thiol derivative 4 requires oxidation and converting it to the sulfonyl chloride intermediate 5. This research aimed to enhance the safety, environmental conditions, and efficiency of the oxidation process by substituting chlorine gas for sodium hypochlorite (commercial bleach). The use of chlorine gas in place of conventional oxidation methods

  乙酰唑酰胺1是一种碳酸酐酶抑制剂，用于医学治疗青光眼、癫痫发作、特发性颅内高压、高原反应等。由相应的硫醇衍生物4合成乙酰唑酰胺需要氧化并将其转化为磺酰氯中间体5。研究旨在通过用氯气替代次氯酸钠（商业漂白剂）来提高氧化过程的安全性、环境条件和效率。使用氯气代替传统的氧化方法带来了显着的好处，包括合成了几种高纯度的新型化合物，特别指定为 6a-6f。这些新型化合物是通过合成的关键磺酰氯 5 与各种胺、腙和双胺前体反应生成的，从而产生了新的磺酰胺衍生物。进行了彻底的研究以确定新合成化合物的抗菌活性（ABA）和抗氧化活性（AOA）。结果表明，预制双产品（7a 和 7b）的 ABA 影响显着高于标准单产品（6a）。这表明，与单一产品相比，双产品具有增强的抗菌特性。此外，合成的肼基产品（8a-8g）对革兰氏阳性菌和革兰氏阴性菌均表现出显着的功效。这些产品，特别是化合物9g，与环丙沙星和四环素等常用抗生