4-(diallylamino)pyridine | 97464-44-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(diallylamino)pyridine
• 英文别名: 4-(N,N-diallylamino)pyridine；N,N-bis(prop-2-enyl)pyridin-4-amine
• CAS: 97464-44-3
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: LPEBRLZPLFOWQC-UHFFFAOYSA-N

物化性质

• 沸点：
  269.3±33.0 °C(Predicted)
• 密度：
  0.985±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(diallylamino)pyridine 在 palladium on activated charcoal 甲烷磺酸 作用下， 以 乙醇 为溶剂， 生成 4-氨基吡啶
  参考文献：
  名称：

  Allyl amines as ammonia equivalents in the preparation of anilines and heteroarylamines

  摘要：

  A series of anilines and heteroarylamines were synthesized in moderate to excellent yields by palladium catalyzed cross coupling reaction of aryl or heteroaryl halides with allyl-or N,N-diallylamine followed by deallylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10877-2
• 作为产物：
  描述：

  4-氯吡啶 、 二烯丙基胺 在 水 、 乙醚 作用下， 130.0 ℃ 、4.44 kPa 条件下， 反应 72.0h， 以to give 4-diallylaminopyridine (11.3 g; 65%; b.p. 92° C. @0.25 torr)的产率得到4-(diallylamino)pyridine
  参考文献：
  名称：

  Process for hydrolyzing esters using 4-aminopyridyl siloxane catalysts

  摘要：

  介绍了一种使用四个二烷基氨基吡啶基团嵌入其聚合物骨架中的硅氧烷作为催化剂，对活性酯进行水解的优选过程。优选的硅氧烷催化剂材料在水解反应中表现出意外的催化效能，以及类酶的酯基底物选择性。

  公开号：

  US05442106A1

文献信息

• RECYCLABLE CATALYSTS FOR ESTERIFICATION OR ACYLATION OF ALCOHOLS
  申请人：LU NORMAN

  公开号：US20120184748A1

  公开（公告）日：2012-07-19

  A compound is useful as a recyclable catalyst for esterification or acylation of alcohols and consists of saccharine and a compound comprising a pyridine moiety. In addition, also a method of preparing the compound and an ester synthesis method using the compound are introduced.

  一种化合物可作为醇的酯化或酰化的可回收催化剂，由糖精和含有吡啶基团的化合物组成。此外，还介绍了一种制备该化合物的方法以及使用该化合物的酯合成方法。
• ZWITTERIONIC CATALYSTS FOR (TRANS)ESTERIFICATION: APPLICATION IN FLUOROINDOLE-DERIVATIVES AND BIODIESEL SYNTHESIS
  申请人：The Chinese University of Hong Kong

  公开号：US20210023539A1

  公开（公告）日：2021-01-28

  An amide/iminium zwitterion catalyst has a catalyst pocket size that promotes transesterification and dehydrative esterification. The amide/iminium zwitterions are easily prepared by reacting aziridines with aminopyridines. The reaction can be applied a wide variety of esterification processes including the large-scale synthesis of biodiesel. The amide/iminium zwitterions allow the avoidance of strongly basic or acidic condition and avoidance of metal contamination in the products. Reactions are carried out at ambient or only modestly elevated temperatures. The amide/iminium zwitterion catalyst is easily recycled and reactions proceed in high to quantitative yields.

  一种酰胺/亚胺兹维特离子催化剂具有促进酯交换和脱水酯化的催化剂口袋尺寸。酰胺/亚胺兹维特离子通过将环氮烷与氨基吡啶反应而容易制备。该反应可应用于各种酯化过程，包括生物柴油的大规模合成。酰胺/亚胺兹维特离子可避免强碱性或酸性条件，并避免产品中的金属污染。反应在常温或仅略微升温下进行。酰胺/亚胺兹维特离子催化剂易于回收，反应产率高且接近定量。
• [EN] NOVEL LIGHT STABILIZERS<br/>[FR] NOUVEAUX STABILISANTS LUMIÈRE
  申请人：BASF SE

  公开号：WO2015004580A1

  公开（公告）日：2015-01-15

  The present invention relates to symmetric diesters of hydroxyalkyl-4-hydroxy- tetraalkylpiperidine compounds and their use as light stabilizers. They are compatible with and soluble in coating formulations of different polarity.

  本发明涉及羟基烷基-4-羟基-四烷基哌啶化合物的对称二酯及其作为光稳定剂的用途。它们与不同极性的涂料配方相容且可溶。
• Process for producing 3-hydroxypropionitrile
  申请人：——

  公开号：US20020040163A1

  公开（公告）日：2002-04-04

  A process for the production of 3-hydroxypropionitrile is provided. This process includes (a) reacting acrylonitrile with water at a defined molar ratio in the presence of a weak base under specific temperature and pressure conditions until a conversion in the range of about 40% to about 80% has been achieved; (b) after cooling the mixture obtained in (a), separating off its aqueous phase; (c) distilling off the acrylonitrile from the organic phase remaining after (b); (d) subjecting the mixture obtained in (c) to pyrolysis at specific temperature and pressure conditions in the presence of a basic catalyst to obtain a mixture consisting mainly of 3-hydroxypropionitrile and acrylonitrile; and (e) isolating the desired 3-hydroxypropionitrile by fractional distillation from the mixture obtained in (d). Such a process in which the basic aqueous phase and the acrylonitrile that has been distilled off are recycled represents a preferred embodiment.

  提供一种生产3-羟基丙腈的方法。该方法包括：(a)在特定的摩尔比下，在弱碱存在的条件下，将丙烯腈与水反应，直到达到约40%至约80%的转化率；(b)冷却(a)步骤得到的混合物后，分离其水相；(c)从(b)步骤后剩余的有机相中蒸馏掉丙烯腈；(d)在特定的温度和压力条件下，在碱性催化剂存在的情况下，对(c)步骤得到的混合物进行热解，以获得主要由3-羟基丙腈和丙烯腈组成的混合物；(e)通过在(d)步骤得到的混合物中进行分馏，从中分离所需的3-羟基丙腈。将基础水相和蒸馏出的丙烯腈进行回收的这种方法代表了一种首选实施方式。
• [EN] RADIOFLUORINATION METHOD<br/>[FR] PROCÉDÉ DE RADIOFLUORINATION
  申请人：UNIV DENMARK TECH DTU

  公开号：WO2014020035A1

  公开（公告）日：2014-02-06

  A method of conducting radiofluorination of a substrate, comprising the steps of: (a) contacting an aqueous solution of [18F] fluoride with a polymer supported phosphazene base for sufficient time for trapping of [18F] fluoride on the polymer supported phosphazene base; and (b) contacting a solution of the substrate with the polymer supported phosphazene base having [18F] fluoride trapped thereon obtained in step (a) for sufficient time for a radiofluorination reaction to take place; an apparatus for conducting radiofluorination; use of the apparatus; and an apparatus for production of a dose of a radiotracer for administration to a patient.

  一种进行底物的放射氟化方法，包括以下步骤：(a)将[18F]氟化物的水溶液与聚合物支撑的磷氮烷碱接触足够长的时间，以使[18F]氟化物被捕集在聚合物支撑的磷氮烷碱上；以及(b)将底物的溶液与在步骤(a)中获得的具有[18F]氟化物被捕集在上面的聚合物支撑的磷氮烷碱接触足够长的时间，以进行放射氟化反应；用于进行放射氟化的装置；使用该装置；以及用于生产用于给患者使用的放射示踪剂剂量的装置。