2-乙基-1,3-二氧戊环-4-甲醇 | 53951-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 中文名称: 2-乙基-1,3-二氧戊环-4-甲醇
• 英文名称: 4-hydroxymethyl-2-ethyl-1,3-dioxolane
• 英文别名: (2-ethyl-[1,3]dioxolan-4-yl)-methanol；(2-Aethyl-[1,3]dioxolan-4-yl)-methanol；2-ethyl-1,3-dioxolane-4-methanol；1,3-Dioxolane-4-methanol, 2-ethyl-；(2-ethyl-1,3-dioxolan-4-yl)methanol
• CAS: 53951-44-3
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: KZODGPRCEZYZRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  2-乙基-1,3-二氧戊环-4-甲醇 、 硫酸二甲酯 在 sodium hydroxide 作用下， 生成 2-ethyl-4-methoxymethyl-[1,3]dioxolane
  参考文献：
  名称：

  Trister; Hibbert, Canadian Journal of Research, Section B: Chemical Sciences, 1936, vol. 14, p. 415,424

  摘要：

  DOI：
• 作为产物：
  描述：

  甘油烯丙基醚 在 tris(triphenylphosphine)ruthenium(II) chloride 作用下， 反应 1.0h， 生成 2-乙基-1,3-二氧戊环-4-甲醇 、 2-ethyl-5-hydroxy-1,3-dioxane
  参考文献：
  名称：

  Highly Selective Isomerization of Allyloxyalcohols to Cyclic Acetals or 1-Propenyloxyalcohols

  摘要：

  根据所使用的过渡金属（Ru、Rh）络合物的不同，烯丙氧基乙醇可以高选择性地异构化为 1-丙烯基衍生物或丙醛的环乙醛。

  DOI：

  10.1055/s-2004-825597

文献信息

• A selective and convenient ruthenium mediated method for the synthesis of mixed acetals and orthoesters
  作者：Stanisław Krompiec、Robert Penczek、Nikodem Kuźnik、Jan Grzegorz Małecki、Marek Matlengiewicz

  DOI：10.1016/j.tetlet.2006.10.138

  日期：2007.1

  and phenols to O-allyl compounds (allyl ethers and acrolein acetals), catalyzed by [RuCl2(PPh3)3], was examined. Intramolecular addition of an OH group, leading to the formation of cyclic acetals and orthoesters, was also investigated. As a result, a new, selective and convenient method for the synthesis of symmetrical and unsymmetrical (mixed) acetals and orthoesters was developed.

  考察了在[RuCl 2（PPh 3）3 ]催化下，将醇和酚添加到O-烯丙基化合物（烯丙基醚和丙烯醛缩醛）中。还研究了分子内加成OH基团，导致形成环缩醛和原酸酯。结果，开发了一种新的，选择性的和方便的合成对称和不对称（混合）乙缩醛和原酸酯的方法。
• Structure–Activity Relationships of WOx-Promoted TiO2–ZrO2 Solid Acid Catalyst for Acetalization and Ketalization of Glycerol towards Biofuel Additives
  作者：Mallesham Baithy、Deboshree Mukherjee、Agolu Rangaswamy、Benjaram M. Reddy

  DOI：10.1007/s10562-021-03733-2

  日期：2022.5

  TiO2–ZrO2 solid acid catalyst was prepared and applied in the catalytic acetalization and ketalization of glycerol with carbonyl compounds to produce biofuel additives. The presence of WOx promoter and TiO2 remarkably improved the catalytic activity of ZrO2. Approximately, 100% glycerol conversion was evidenced with non-bulky aliphatic aldehydes and ketones like, propanol and cyclohexanone. The physical

  摘要 制备了WO x促进的TiO 2 -ZrO 2固体酸催化剂，并将其应用于甘油与羰基化合物的催化缩醛化和缩酮化生产生物燃料添加剂。WO x助剂和TiO 2的存在显着提高了ZrO 2的催化活性。大约 100% 的甘油转化被非大体积脂肪醛和酮（如丙醇和环己酮）证明。WO x促进的TiO 2 -ZrO 2的物理表征揭示了 ZrO 2的四方晶相的较高形成，超过单斜。总表面酸度和布朗斯台德与路易斯酸性位点浓度之比分别通过 NH 3 -TPD 和吡啶化学吸附 FTIR 光谱测定。在 WO x促进的TiO 2 -ZrO 2催化剂表面上证明了明显更高浓度的路易斯酸性位点，约 213.29 μmol/gm 。催化活性研究揭示了表面路易斯酸性位点浓度与催化剂活性之间的直接相关性。这一重要观察表明路易斯酸性位点在该催化过程中的关键作用。WO x促进的TiO 2 –ZrO 2催化剂也相当稳定，在甘油与其他取代羰
• Methods to Manufacture 1,3-Dioxolane Nucleosides
  申请人：Sznaidman Marcos

  公开号：US20110130559A1

  公开（公告）日：2011-06-02

  This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (−)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for preparing a substantially pure β-D- or β-L-1,3-dioxolane nucleosides comprising a) preparing or obtaining an esterified 2,2-dialkoxy ethanol; b) cyclizing the esterified 2,2-dialkoxy ethanol with glycolic acid to obtain a 1,3-dioxolane lactone; c) resolving the 1,3-dioxolane lactone to obtain a substantially pure D- or L-lactone; d) selectively reducing and activating the D- or L-chiral lactone to obtain a substantially pure D- or L-1,3-dioxolane; e) coupling the D- or L-1,3-dioxolane to an activated and/or protected purine or pyrimidine base; and f) optionally purifying the nucleoside to obtain a substantially pure protected β-D- or β-L-1,3-dioxolane nucleoside.

  该应用程序提供了一种制备对映纯的β-D-二氧杂环己烷核苷的方法。特别地，描述了一种适用于大规模开发的(−)-DAPD的新合成方法。在一种实施例中，该发明提供了一种制备基本纯的β-D-或β-L-1,3-二氧杂环己烷核苷的方法，包括a) 准备或获得酯化的2,2-二烷氧基乙醇; b) 用乙醇酸环化酯化的2,2-二烷氧基乙醇以获得1,3-二氧杂环己烷内酯; c) 分离1,3-二氧杂环己烷内酯以获得基本纯的D-或L-内酯; d) 选择性还原和激活D-或L-手性内酯以获得基本纯的D-或L-1,3-二氧杂环己烷; e) 将D-或L-1,3-二氧杂环己烷偶联到活化和/或保护的嘌呤或嘧啶碱基上; f) 可选地纯化核苷酸以获得基本纯的保护的β-D-或β-L-1,3-二氧杂环己烷核苷。
• IMAGE FORMING METHOD
  申请人：GOTOU Hiroshi

  公开号：US20130155145A1

  公开（公告）日：2013-06-20

  An image forming method applying a pretreatment liquid on the surface of a recording medium; and applying an inkjet ink including a colorant, a hydrosoluble organic solvent, a surfactant and water on the surface applied with the pretreatment liquid, wherein the hydrosoluble organic solvent includes at least one polyol including an equilibrium water content in an amount not less than 30% by weight at 23° C. and 80% RH; an amide compound having the following formula (I); and at least one of compounds having the following formulae (II) to (IV), and wherein a pure water transfers to the recording medium in an amount of from 1 to 15 mL/m 2 when measured by a dynamic scanning liquid absorptometer at a contact time of 100 ms.

  一种图像形成方法，其在记录介质的表面上应用预处理液，并在应用预处理液的表面上应用包括颜料、水溶性有机溶剂、表面活性剂和水的喷墨墨水，其中水溶性有机溶剂包括至少一种多元醇，其在23℃和80%相对湿度下的平衡含水量不少于30%（重量百分比），具有以下式（I）的酰胺化合物，以及具有以下式（II）至（IV）之一的化合物，其中在100ms接触时间下，通过动态扫描液体吸收计测量，纯水向记录介质转移的量为1至15 mL/m2。
• ——
  作者：A. S. Shevchuk、V. A. Podgornova、O. P. Yablonskii

  DOI：10.1023/a:1012730603208

  日期：——

  The feasibility of preparing dioxolanylmethyl methacrylates from aldehydes in two stages (without purification of intermediate 4-hydroxymethyl-1,3-dioxane) was examined.