3-(4-Methylsulfonylphenoxy)-5-pyridin-2-yloxybenzoic acid | 1001420-89-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-Methylsulfonylphenoxy)-5-pyridin-2-yloxybenzoic acid
• CAS: 1001420-89-8
• 化学式: C₁₉H₁₅NO₆S
• 分子量: 385.397
• InChiKey: SOYKSDHCFFENBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 3-(2-aminothiazol-5-yl)oxybenzoate 、 3-(4-Methylsulfonylphenoxy)-5-pyridin-2-yloxybenzoic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 以25%的产率得到Methyl 3-[[2-[[3-(4-methylsulfonylphenoxy)-5-pyridin-2-yloxybenzoyl]amino]-1,3-thiazol-5-yl]oxy]benzoate
  参考文献：
  名称：

  WO2008/154563

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氯吡啶 、 3-羟基-5-(4-(甲基磺酰基)苯氧基)苯甲酸甲酯 在 potassium carbonate 、 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 以21%的产率得到3-(4-Methylsulfonylphenoxy)-5-pyridin-2-yloxybenzoic acid
  参考文献：
  名称：

  WO2008/154563

  摘要：

  公开号：

文献信息

• PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2059522B1

  公开（公告）日：2014-01-08
• 1,3-DIHYDROXY SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS
  申请人：Chen Sean

  公开号：US20100179121A1

  公开（公告）日：2010-07-15

  Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R 1 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R 2 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R 5 is as defined herein; Z is O, S, S(O), S(O)2, or NR 5a ; X is S, O, N, NR 3 , or CR 3 ; Y is NCR 4 or NR 4 ; R 3 , R 4 , and R 5 are as defined herein; R 8 is aryl, heteroaryl, —PO(OR 9 )(OR 10 ), —PO(OR 9 )R 10 or —P(O)(R 9 )R 10 (wherein R 9 and R 10 are as defined herein)/R 6 and R 7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
• NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME
  申请人：Ryono Denis E.

  公开号：US20120142636A1

  公开（公告）日：2012-06-07

  Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure is a heteroaryl ring; R 4 is —(CH 2 ) n —Z—(CH 2 ) m —PO(OR 7 )(OR 8 ), —(CH 2 ) n Z—(CH 2 ) m —PO(OR 7 )R 9 , —(CH 2 ) n —Z—(CH 2 ) m —OPO(OR 7 )R 9 , —(CH 2 ) n Z—(CH 2 ) m —OPO(R 9 )(R 10 ), or —(CH 2 ) n Z—(CH 2 ) m —PO(R 9 )(R 10 ); R 5 and R 6 are independently selected from H, alkyl and halogen; Y is R 7 (CH 2 ) s or is absent; and X, n, Z, m, R 4 , R 5 , R 6 , R 7 , and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
• US8153677B2
  申请人：——

  公开号：US8153677B2

  公开（公告）日：2012-04-10
• US8222285B2
  申请人：——

  公开号：US8222285B2

  公开（公告）日：2012-07-17