N-benzoylthreonine | 857780-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoylthreonine
• 英文别名: N-Benzoyl-DL-threonin；DL-N-Benzoylthreonin；N-Benzoyl-DL-threonine；2-benzamido-3-hydroxybutanoic acid
• CAS: 857780-50-8
• 化学式: C₁₁H₁₃NO₄
• mdl: MFCD00067631
• 分子量: 223.229
• InChiKey: IOQIWWTVXOPYQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-benzoylthreonine 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以61%的产率得到4-ethylidene-2-phenyl-5-oxazolone
  参考文献：
  名称：

  Thionation of N-Acylthreonine and Its Methyl Ester with Lawesson's Reagent: Synthesis of 5-Oxazolones, 5-Thiazolones and Thiazolines

  摘要：

  DOI：

  10.3987/com-00-s(i)17
• 作为产物：
  描述：

  DL-Threonine 、 苯甲酰氯 以 1,4-二氧六环 、 水 为溶剂， 生成 N-benzoylthreonine
  参考文献：
  名称：

  Kuritsyn, L. V.; Kalinina, N. V., Russian Journal of Organic Chemistry, 1994, vol. 30, # 5.2, p. 767 - 770

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS<br/>[FR] PROCESSUS DE PRÉPARATION DE COMPOSÉS INHIBITEURS DE RHO-KINASE
  申请人：INSPIRE PHARMACEUTICALS INC

  公开号：WO2009154940A1

  公开（公告）日：2009-12-23

  The present invention is directed to practical high-yielding synthetic processes to prepare compounds of general Formula III, IV, V, VII, VIII, IX, X, XII, XIV, and XV. Such compounds are useful as final products or can be used as intermediates and be further modified to prepare other desired products such as rho-kinase inhibitors. The present invention is also directed to certain novel compounds and/or novel solid forms of certain compounds.

  本发明旨在提供实用的高产率合成工艺，用于制备一般化学式III、IV、V、VII、VIII、IX、X、XII、XIV和XV的化合物。这些化合物可用作最终产品，也可用作中间体，并可进一步修改以制备其他所需产品，如rho-激酶抑制剂。本发明还涉及某些新颖化合物和/或某些化合物的新颖固体形式。
• PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS
  申请人：She Jin

  公开号：US20100022775A1

  公开（公告）日：2010-01-28

  The present invention is directed to practical high-yielding synthetic processes to prepare compounds of general Formula III, IV, V, VII, VIII, IX, X, XII, XIV, and XV. Such compounds are useful as final products or can be used as intermediates and be further modified to prepare other desired products such as rho-kinase inhibitors. The present invention is also directed to certain novel compounds and/or novel solid forms of certain compounds.

  本发明涉及实用的高产率合成过程，用于制备通式III、IV、V、VII、VIII、IX、X、XII、XIV和XV的化合物。这些化合物可用作最终产品，也可用作中间体，并进一步改性以制备其他所需产品，如rho-激酶抑制剂。本发明还涉及某些新颖化合物和/或某些化合物的新颖固态形式。
• Method for producing L-threonine by fermentation
  申请人：AJINOMOTO CO., INC.

  公开号：EP0066129A2

  公开（公告）日：1982-12-08

  New L-threonine-producing strains of the genus Brevibacterium and Corynebacterium are obtained by separating a plasmid DNA from a microorganism of the genus Brevibacterium and Corynebacterium, inserting into the plasmid DNA a fragment of chromosomal DNA derived from a DNA-donor strain of the genus Brevibacterium or Corynebacterium resistant to a-amino-p-hydroxy valeric acid to obtain a recombinant plasmid DNA, incorporating the recombinant plasmid DNA into a recipient strain of the genus Brevibacterium or Corynebacterium which is sensitive to α-amino-β-hydroxy valeric acid and isolating a strain transformed to become resistant to α-amino-β-hydroxy-valeric acid. By aerobically cultivating the new strains in an aqueous culture medium L-threonine may be obtained in high yields.

  通过从乳杆菌属和棒状杆菌属微生物中分离出质粒 DNA，将来自乳杆菌属或棒状杆菌属对 α-氨基-对羟基戊酸敏感的 DNA 供体菌株的染色体 DNA 片段插入质粒 DNA 中，获得重组质粒 DNA，从而获得乳杆菌属和棒状杆菌属产 L-苏氨酸的新菌株、将重组质粒 DNA 植入对 α-氨基-β-羟基戊酸敏感的 Brevibacterium 或 Corynebacterium 受体菌株中，并分离出对 α-氨基-β-羟基戊酸具有抗性的转化菌株。 通过在水培养基中对新菌株进行有氧培养，可以获得高产率的 L-苏氨酸。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0226304B1

  公开（公告）日：1991-08-28
• PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：UNIVERSITY OF PITTSBURGH

  公开号：EP0959884A1

  公开（公告）日：1999-12-01