1-苯硫基丙-2-胺 | 2014-77-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 1-苯硫基丙-2-胺
• 英文名称: 1-methyl-2-(phenylsulfanyl)ethylamine
• 英文别名: 1-methyl-2-phenylmercaptoethylamine；1-phenylsulfanyl-2-propanamine；1-(Phenylthio)-2-aminopropane；1-(phenylthio)propan-2-amine；β-phenylsulfanyl-isopropylamine；β-Phenylmercapto-isopropylamin；1-phenylsulfanylpropan-2-amine
• CAS: 2014-77-9
• 化学式: C₉H₁₃NS
• 分子量: 167.275
• InChiKey: YAUHFKDKQAMMJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  1-苯硫基丙-2-胺 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 1.5h， 生成 7-Piperazinyl-6-fluoro-1-(2-(phenylsulfinyl)-1-methylethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationship of new 1-substituted derivatives

  摘要：

  A series of novel 7-piperazinyl-1-substituted-6-fluoroquinolones and naphthyridines have been prepared and their antibacterial activities evaluated. These derivatives are characterized by having alkyl, alkenyl, arylalkyl, cycloalkyl, and cycloalkenyl groups at the 1-position. As a result of this study, derivatives 7 and 26, which are substituted with tert-butyl groups at N-1, were found to possess excellent in vitro and in vivo potency, particularly against Staphylococcus aureus, comparable to that of norfloxacin or ciprofloxacin. Structure-activity relationships of N-1 substituted alkyls and cycloalkyls are also discussed.

  DOI：

  10.1021/jm00123a005
• 作为产物：
  描述：

  N-<2-Phenylmercapto-1-methyl-aethyl>-acetamid 在 盐酸 作用下， 生成 1-苯硫基丙-2-胺
  参考文献：
  名称：

  N-(Arylmercaptoalkyl) Amides by Reaction of Thiols with Amino Alcohols and Carboxylic Acids

  摘要：

  DOI：

  10.1021/jo01045a025

文献信息

• Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators
  作者：Damiano Tanini、Antonella Capperucci、Claudiu T. Supuran、Andrea Angeli

  DOI：10.1016/j.bioorg.2019.03.062

  日期：2019.6

  A new series of β-aminochalcogenides were designed and synthesized to identify new carbonic anhydrase activator (CAA) agents as novel tools for the management of several neurodegenerative and metabolic disorders which represent a clinical challenge without effective therapies available. Some β-aminoselenides and β-aminotellurides showed effective CA activating effects and a potent antioxidant activity

  设计并合成了一系列新的β-氨基硫属元素化物，以鉴定新的碳酸酐酶激活剂（CAA），作为治疗几种神经退行性和代谢性疾病的新工具，这代表了在没有有效治疗方法的情况下的临床挑战。一些β-氨基硒化物和β-氨基碲化物显示出有效的CA活化作用和有效的抗氧化活性。CAA可用于记忆疗法和CA缺乏症候群。
• Synthesis, fungicidal activity and SAR of new amino acid derivatives containing substituted 1-(phenylthio)propan-2-amine moiety
  作者：Lei Tian、Yang Gao、Xing-Jie Peng、Cheng Zhang、Wei-Guang Zhao、Xing-Hai Liu

  DOI：10.1080/10426507.2021.2012471

  日期：2022.2.1

  Abstract Fifteen novel amino acid derivatives were designed and synthesized using natural amino acid L-valine and two non-natural amino acids as raw materials. Fungicidal activities of these amino acid derivatives were tested against Phytophthora capsici. Most of these compounds possessed excellent activity against Phytophthora capsici at 50 μg/mL. Interestingly, compound isopropyl ((2S)-1-((1-((4

  摘要 以天然氨基酸L-缬氨酸和两种非天然氨基酸为原料，设计合成了15种新型氨基酸衍生物。测试了这些氨基酸衍生物对辣椒疫霉的杀真菌活性。这些化合物中的大多数在 50 μg/mL 时对辣椒疫霉具有优异的活性。有趣的是，化合物异丙基 ((2S)-1-((1-((4-fluorophenyl)thio)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 5c (EC 50 = 0.43 μg/mL)，异丙酯 ((2S)-1-((1-((3,4-二甲氧基苯基)硫代)丙-2-基)氨基)-3-甲基-1-氧代丁-2-基)氨基甲酸酯5g (EC 50 =0.49 μg/mL)，异丙基((2S)-1-((1-((4-(乙炔氧基)苯基)硫基)丙-2-基)氨基)-3-甲基-1-氧代丁烷-2-基)氨基甲酸酯5h(EC 50 =0.15 μg/mL)和异丙基((2S
• 1-Phenylthio-2-aminopropane derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0053015A1

  公开（公告）日：1982-06-02

  Novel 1-phenylthio-2-aminopropane derivatives, inclusive of salts thereof, of the formula: wherein R1 is halogen, R2 is hydrogen or halogen and R3 is methyl, ethyl or hydroxyethyl, have antiobesity and antidiabetic actions.

  新颖的 1-苯硫基-2-氨基丙烷衍生物（包括其盐类）具有抗肥胖和抗糖尿病作用： 其中 R1 为卤素，R2 为氢或卤素，R3 为甲基、乙基或羟乙基，具有抗肥胖和抗糖尿病作用。
• 1-Tert-alkyl-substituted naphthyridine and quinoline carboxylic acids as antibacterial agents
  申请人：Bristol-Myers Squibb Company

  公开号：EP0266576A2

  公开（公告）日：1988-05-11

  There are disclosed new naphthyridine-and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine-and quinoline-carboxylic acids.

  本发明公开了具有 1-叔烷基取代基的新型萘啶酸和喹啉羧酸、含有它们的组合物以及它们在治疗温血动物细菌感染中的用途。此外，还公开了用于制备萘啶和喹啉羧酸的新型胺和中间体。
• ORGANIC COMPOUNDS CONTAINING HETEROATOMS AND THEIR USE IN ZIEGLER-NATTA CATALYST WITH SINGLE ACTIVATION CENTER
  申请人：SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES

  公开号：EP2039677A1

  公开（公告）日：2009-03-25

  Organic compounds containing heteroatoms and their use in preparing Ziegler-Natta (Z-N) catalyst with single activation center. The Z-N olefin polymerization catalyst is prepared by adding organic or inorganic solid carrier or compound of them which is pre-activated by heating or pre-treated chemically, organic compound containing heteroatoms and metallic compound into magnesium compound/tetrahydrofuran solution. The Z-N olefin polymerization catalyst prepared in the present invention is fluidizable powder and can prepare ethene homopolymer and copolymer of controllable construction with high catalytic activity, during homo-polymerization and combined polymerization with alpha-olefin of C3-C8 under action of catalyst promoter such as alkyl aluminium, alkyl aluminoxane, and so on.

  含有杂原子的有机化合物及其在制备具有单活化中心的齐格勒-纳塔（Z-N）催化剂中的应用。Z-N 烯烃聚合催化剂的制备方法是在镁化合物/四氢呋喃溶液中加入经加热预活化或化学预处理的有机或无机固体载体或它们的化合物、含杂原子的有机化合物和金属化合物。本发明制备的 Z-N 烯烃聚合催化剂为可流动粉末，在烷基铝、烷基铝氧烷等催化剂促进剂的作用下，与 C3-C8 α-烯烃进行均聚和联合聚合时，可制备结构可控、催化活性高的乙烯均聚物和共聚物。