The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I. The preparation method has high yield, requires less purification operations, and is suitable for industrial application.
该申请属于制药
化学领域,涉及一种制备
胆酸化合物的方法。具体来说,该申请提供了制备式I化合物的方法,包括将式2化合物进行氧化反应得到式3化合物;将式3化合物连接三甲基
硅基团得到式4化合物;将式4化合物与
乙醛反应得到式5化合物;将式5化合物进行催化氢化反应得到式6化合物;将式6化合物的
氰基转化为羧基得到式I化合物。该制备方法产率高,需要较少的纯化操作,适合工业应用。