2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethylamine
• 英文别名: 2-(3-methoxy-4-prop-2-ynoxyphenyl)ethanamine
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: LMUZMTWFXPYIEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethylamine 生成 2,2-dichloro-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]acetamide
  参考文献：
  名称：

  HIRAL, KENTARO;MIZUSHIMA, YUKIO

  摘要：

  DOI：

文献信息

• Phenyl-propargylether derivatives
  申请人：Syngenta Crop Protection, Inc.

  公开号：US06683211B1

  公开（公告）日：2004-01-27

  The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is halogen, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkenylthio; optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenylsulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl or optionally substituted alkynylsulfonyl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

  该发明涉及一般式I的苯基-丙炔醚衍生物，包括其光学异构体和这些异构体的混合物，其中 R1为氢、烷基、环烷基或可选择取代的芳基， R2和R3分别独立为氢或烷基， R4为烷基、烯基或炔基， R5、R6、R7和R8分别独立为氢或烷基， R9为氢、可选择取代的烷基、可选择取代的烯基或可选择取代的炔基， R10为可选择取代的芳基或可选择取代的杂环芳基，以及 Z为卤素、可选择取代的芳氧基、可选择取代的烷氧基、可选择取代的烯氧基、可选择取代的炔氧基、可选择取代的芳硫基、可选择取代的烷硫基、可选择取代的烯硫基、可选择取代的炔硫基、可选择取代的烷亚砜基、可选择取代的烯亚砜基、可选择取代的炔亚砜基、可选择取代的烷砜基、可选择取代的烯砜基或可选择取代的炔砜基。这些化合物具有有用的植物保护性能，并可有利地用于农业实践中，用于控制或预防植物受植物病原微生物，特别是真菌的侵害。
• [EN] PROCESSES FOR THE PREPARATION OF AMIDES<br/>[FR] PROCÉDÉS DE PRÉPARATION D'AMIDES
  申请人：SYNGENTA LTD

  公开号：WO2009138372A1

  公开（公告）日：2009-11-19

  The invention relates to a process for the preparation of intermediates useful in the preparation of fungicidally active phenylpropargylether derivatives. The process involves coupling of carboxylic acid with an amine in (a) the absence of a catalyst; (b) the presence of a boronic acid catalyst.

  这项发明涉及一种用于制备在制备具有杀真菌活性的苯丙炔醚衍生物时有用的中间体的方法。该方法涉及在以下情况下将羧酸与胺偶联：(a) 在无催化剂的情况下；(b) 在硼酸催化剂存在的情况下。
• HIRAL, KENTARO;MIZUSHIMA, YUKIO
  作者：HIRAL, KENTARO、MIZUSHIMA, YUKIO

  DOI：——

  日期：——
• NOVEL PHENYL-PROPARGYLETHER DERIVATIVES
  申请人：Syngenta Participations AG

  公开号：EP1282595B1

  公开（公告）日：2004-07-14
• PROCESSES FOR THE PREPARATION OF AMIDES
  申请人：Bowden Martin Charles

  公开号：US20110071315A1

  公开（公告）日：2011-03-24

  The invention relates to a process for the preparation of intermediates useful in the preparation of fungicidally active phenylpropargylether derivatives. The process involves coupling of carboxylic acid with an amine in (a) the absence of a catalyst; (b) the presence of a boronic acid catalyst.