tripartilactam

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: tripartilactam
• 英文别名: (1R,2E,4E,11R,12E,14E,16E,18S,19R,20Z,22R,23R,24R,26R)-22,23,24-trihydroxy-3,11,17-trimethyl-9-azatricyclo[16.8.0.019,26]hexacosa-2,4,12,14,16,20-hexaene-6,8,25-trione
• 化学式: C₂₈H₃₅NO₆
• 分子量: 481.589
• InChiKey: JJPNUGKSPSWMDS-WDKWOEEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  35
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tripartilactam 在 臭氧 、 双氧水 、 溶剂黄146 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 21.08h， 生成 (2S)-3-氨基-2-甲基丙酸
  参考文献：
  名称：

  Tripartilactam, a Cyclobutane-Bearing Tricyclic Lactam from aStreptomycessp. in a Dung Beetle’s Brood Ball

  摘要：

  Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na+/K+ ATPase inhibitor (IC50 = 16.6 mu g/mL).

  DOI：

  10.1021/ol300108z

文献信息

• Tripartilactam, a Cyclobutane-Bearing Tricyclic Lactam from a<i>Streptomyces</i>sp. in a Dung Beetle’s Brood Ball
  作者：Seon-Hui Park、Kyuho Moon、Hea-Son Bang、Seong-Hwan Kim、Dong-Gyu Kim、Ki-Bong Oh、Jongheon Shin、Dong-Chan Oh

  DOI：10.1021/ol300108z

  日期：2012.3.2

  Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na+/K+ ATPase inhibitor (IC50 = 16.6 mu g/mL).