Ethyl 2-[(3-methylquinoxalin-2-yl)methoxy]benzoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Ethyl 2-[(3-methylquinoxalin-2-yl)methoxy]benzoate
• 化学式: C₁₉H₁₈N₂O₃
• 分子量: 322.364
• InChiKey: MXUBSOLVQFLTSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethyl 2-[(3-methylquinoxalin-2-yl)methoxy]benzoate 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 2-(3-methyl-quinoxalin-2-ylmethoxy)-benzoic acid hydrazide
  参考文献：
  名称：

  Quinoxalines. IX. Reaction of 2-(Halogenomethyl)-quinoxalines and -quinoline with hydroxybenzoic acids and their esters

  摘要：

  In the presence of a base the title compounds react to products with ether structure (4,6), or with ester structure (3), or to structure 5 containing both functionalities in dependence on the mole ratio of the starting substances, on reaction conditions and on the substituent patterns in the hydroxybenzoic acid component.Under the influence of alkali hydroxide the m- and p-substituted compounds (6e-g) are saponified to the alkali salts of the carboxylic acid (4b,c). The o-substituted compounds (6a-d), however, are cyclized to the benzo[b]furanylquinoxalines (8). 8a, d are also obtained by thermal water elimination of the carboxylic acids 4a, d, The red-coloured benzofuranols 8 react with acetic anhydride and benzoyl-chloride/pyridine, resp., to the weakly yellow esters 9.The structure of the products 8 and 9 is studied by UV-VIS derivative spectroscopy, by theoretical calculation of the dihedral angles and by H-1 and C-13 NMR spectroscopy. The H-1 and C-13 chemical shifts are completely assigned. The quinoxalines 8a-c and the quinoline 8d only exist in the hydroxy form.

  DOI：

  10.1002/prac.199733901130
• 作为产物：
  描述：

  2-(溴甲基)-3-甲基喹喔啉 、 水杨酸乙酯 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以53%的产率得到Ethyl 2-[(3-methylquinoxalin-2-yl)methoxy]benzoate
  参考文献：
  名称：

  Quinoxalines. IX. Reaction of 2-(Halogenomethyl)-quinoxalines and -quinoline with hydroxybenzoic acids and their esters

  摘要：

  In the presence of a base the title compounds react to products with ether structure (4,6), or with ester structure (3), or to structure 5 containing both functionalities in dependence on the mole ratio of the starting substances, on reaction conditions and on the substituent patterns in the hydroxybenzoic acid component.Under the influence of alkali hydroxide the m- and p-substituted compounds (6e-g) are saponified to the alkali salts of the carboxylic acid (4b,c). The o-substituted compounds (6a-d), however, are cyclized to the benzo[b]furanylquinoxalines (8). 8a, d are also obtained by thermal water elimination of the carboxylic acids 4a, d, The red-coloured benzofuranols 8 react with acetic anhydride and benzoyl-chloride/pyridine, resp., to the weakly yellow esters 9.The structure of the products 8 and 9 is studied by UV-VIS derivative spectroscopy, by theoretical calculation of the dihedral angles and by H-1 and C-13 NMR spectroscopy. The H-1 and C-13 chemical shifts are completely assigned. The quinoxalines 8a-c and the quinoline 8d only exist in the hydroxy form.

  DOI：

  10.1002/prac.199733901130

文献信息

• Quinoxalines. IX. Reaction of 2-(Halogenomethyl)-quinoxalines and -quinoline with hydroxybenzoic acids and their esters
  作者：G. Sarodnick、L. Hilfert、G. Kempter、E. Kleinpeter

  DOI：10.1002/prac.199733901130

  日期：——

  In the presence of a base the title compounds react to products with ether structure (4,6), or with ester structure (3), or to structure 5 containing both functionalities in dependence on the mole ratio of the starting substances, on reaction conditions and on the substituent patterns in the hydroxybenzoic acid component.Under the influence of alkali hydroxide the m- and p-substituted compounds (6e-g) are saponified to the alkali salts of the carboxylic acid (4b,c). The o-substituted compounds (6a-d), however, are cyclized to the benzo[b]furanylquinoxalines (8). 8a, d are also obtained by thermal water elimination of the carboxylic acids 4a, d, The red-coloured benzofuranols 8 react with acetic anhydride and benzoyl-chloride/pyridine, resp., to the weakly yellow esters 9.The structure of the products 8 and 9 is studied by UV-VIS derivative spectroscopy, by theoretical calculation of the dihedral angles and by H-1 and C-13 NMR spectroscopy. The H-1 and C-13 chemical shifts are completely assigned. The quinoxalines 8a-c and the quinoline 8d only exist in the hydroxy form.