仲丁基肼 | 30924-14-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 仲丁基肼
• 英文名称: 2-sec-butyl-hydrazine
• 英文别名: sec-butylhydrazine；sec-butyl-hydrazine；sec-Butyl-hydrazin；sek.-Butyl-hydrazin；2-Hydrazino-butan；secbutylhydrazin；butan-2-ylhydrazine
• CAS: 30924-14-2
• 化学式: C₄H₁₂N₂
• 分子量: 88.1527
• InChiKey: SFSUYFSIKDDLOL-UHFFFAOYSA-N

物化性质

• 沸点：
  102-109 °C
• 密度：
  0.820±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  氰基丙酮 、 仲丁基肼 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 1-SEC-丁基-3-甲基-1H-吡唑-5-胺
  参考文献：
  名称：

  Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

  摘要：

  The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

  DOI：

  10.1016/j.bmcl.2019.01.027
• 作为产物：
  描述：

  N-t-butoxycarbonyl-N'-sec-butyl hydrazine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 仲丁基肼
  参考文献：
  名称：

  Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

  摘要：

  The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

  DOI：

  10.1016/j.bmcl.2019.01.027

文献信息

• Heilmittelchemische Studien in der heterocyclischen Reihe. 26. Mitteilung
  作者：P. Schmidt、K. Eichenberger、M. Wilhelm、J. Druey

  DOI：10.1002/hlca.19590420318

  日期：——

  Syntheses of pyrazolo [3,4-d]pyrimidines with an amino group in 3- or 4-position are described. For the preparation of the 3-amino derivatives a 4-chloro-5-cyano-pyrimidine is condensed with various hydrazines. The 4-amino-pyrazolo [3,4-d]pyrimidines are obtained by reacting 3-amino-4-carbethoxy-pyrazoles with formamide, chlorinating thc 4-hydroxy-pyrazolo [3,4-d]pyrimidines, and substituting the halogen

  描述了在3-或4-位具有氨基的吡唑并[3,4-d]嘧啶的合成。为了制备3-氨基衍生物，将4-氯-5-氰基-嘧啶与各种肼缩合。4-氨基-吡唑并[3,4-d]嘧啶是通过使3-氨基-4-碳乙氧基-吡唑与甲酰胺反应，氯化4-羟基-吡唑并[3,4-d]嘧啶并取代卤素而获得的。通过氨基。一些化合物表现出利尿和心脏活性，另一些则抑制肿瘤的生长。
• [EN] THIENYLPYRI (MI) DINYLAZOLE AND THEIR USE FOR CONTROLLING PHYTOPATHOGENIC FUNGI<br/>[FR] THIÉNYLPYRI(MI)DINYLAZOLE ET UTILISATION ASSOCIÉE DANS LA LUTTE CONTRE DES CHAMPIGNONS PHYTOPATHOGÈNES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2011076725A1

  公开（公告）日：2011-06-30

  Thienylpyri(mi)dinylazole of the formula (I) in which R1 to R8 and X1 have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seed of plants and for reducing mycotoxins in plants and parts of the plants, to processes for preparing such compounds and compositions and treated seed and also to their use for controlling phytopathogenic harmful fungi in agriculture, horticulture, forestry, in animal husbandry, in the protection of materials, in the domestic and hygiene field and for the reduction of mycotoxins in plants and parts of the plants.

  该文描述了化合物公式（I）中的Thienylpyri（mi）dinylazole，其中R1至R8和X1的含义在描述中给出，以及其农药活性盐，其用途以及用于控制植物或种子中和/或植物或其部位中的植物病原真菌和减少植物中真菌毒素的方法和组合物，以及制备此类化合物和组合物以及处理过的种子的过程，也包括它们在农业、园艺、林业、畜牧业、材料保护、家庭和卫生领域中控制植物病原真菌和减少植物及其部位中真菌毒素的用途。
• Thienylpyri(mi)dinylazole
  申请人：Es-Sayed Mazen

  公开号：US20110237588A1

  公开（公告）日：2011-09-29

  Thienylpyri(mi)dinylazole of the formula (I) in which R 1 to R 8 and X 1 have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seed of plants and for reducing mycotoxins in plants and parts of the plants, to processes for preparing such compounds and compositions and treated seed and also to their use for controlling phytopathogenic harmful fungi in agriculture, horticulture, forestry, in animal husbandry, in the protection of materials, in the domestic and hygiene field and for the reduction of mycotoxins in plants and parts of the plants.

  该专利涉及一种化合物及其农药活性盐，其化学式为（I），其中R1至R8和X1的含义在说明中给出，以及其在植物或种子中控制植物病原真菌和减少植物和植物部分中真菌毒素的方法和组合物，以及制备这种化合物和组合物和处理种子的过程，以及它们在农业、园艺、林业、动物饲养、材料保护、家庭卫生领域中控制植物病原真菌和减少植物和植物部分中真菌毒素的用途。
• Jensen,K.A. et al., Acta Chemica Scandinavica (1947), 1968, vol. 22, p. 1 - 50
  作者：Jensen,K.A. et al.

  DOI：——

  日期：——
• Jensen,K.A. et al., Acta Chemica Scandinavica (1947), 1961, vol. 15, p. 1109 - 1123
  作者：Jensen,K.A. et al.

  DOI：——

  日期：——