Cetyl linolenate | 1272984-91-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Cetyl linolenate
• 英文别名: hexadecyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• CAS: 1272984-91-4
• 化学式: C₃₄H₆₂O₂
• 分子量: 502.865
• InChiKey: SVUULQMAQXFENX-JTBMWNAQSA-N

物化性质

• 保留指数：
  3522.64

计算性质

• 辛醇/水分配系数(LogP)：
  14
• 重原子数：
  36
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Γ-十八碳三烯酸 、 1-十六烷醇 在 lipase 作用下， 以 正己烷 为溶剂， 反应 4.0h， 以94%的产率得到Cetyl linolenate
  参考文献：
  名称：

  Nishio, Toshiyuki; Kamimura, Minoru, Agricultural and Biological Chemistry, 1988, vol. 52, # 11, p. 2933 - 2936

  摘要：

  DOI：

文献信息

• WO2006/64685
  申请人：——

  公开号：——

  公开（公告）日：——
• Transdermal delivery of medicaments with combinations of cetylated fatty fatty ester penetrant complexes
  申请人：Barathur Raj R.

  公开号：US20110065627A1

  公开（公告）日：2011-03-17

  This invention describes a topical delivery mechanism that contains a mixture of cetylated fatty esters that act as transdermal carriers of desired therapeutic molecules. The proposed cetyl fatty ester penetrant-complex (Base CFEP-complex) contains specific cetyl fatty esters, polar solvents, a carrier base (gel, cream, lotion, patch or stick gel), antioxidants and the desired pharmaceutical, cosmetic or antigenic response eliciting molecules that are efficaciously delivered by selectively varying component ratios in the complex. The invention proposes the use of transdermal delivery of medications such as those used in treatment of urinary incontinence, testosterone deficiency, arthritic and joint pain and other pains such as pain in the neck, lower back, back, knees, headaches, and other types of inflammatory pains, peripheral neuropathic pain, pain associated with repetitive strain injuries such as myofacial pain, rapid treatment of epileptic seizures, soluble antigens in the immuno-therapeutic treatment of allergies, actives in the treatment of foot cracks and elbow cracks, actives in the treatment of facial and other wrinkles in the form of anti-aging creams and gels and other topically delivered therapies.
• TOPICAL DERMAL DELIVERY COMPOSITIONS USING SELF ASSEMBLING NANOPARTICLES WITH CETYLATED COMPONENTS
  申请人：Barathur Raj R.

  公开号：US20140234428A1

  公开（公告）日：2014-08-21

  The invention, a transdermal delivery method, relates to penetration-enhancing pharmaceutical compositions comprising a novel, stable mixture of cetylated esters, cetyl or stearyl alcohols, polar solvents and surfactants, which, under appropriate conditions, combine into amphiphilic nanoparticles within a stabilized liquid dispersion for use in delivery of medicinal agents through the skin. The term cetosomes is used to describe these particles in order to differentiate them from other nanoparticles, such as niosomes, cerasomes, polymeric micelles, dendrimers, liposomes, lipoids, solid lipid nanoparticles and other particles. The self-assembling cetosomes, with both ionic and nonionic points of attraction, incorporate and concentrate a variety of different bioactive agents of interest and demonstrate stable properties with similarities to colloidal molecular structures. The compositions enhance topical transdermal fluxes of bioactives without permanently disrupting natural skin barrier function.
• US8394759B2
  申请人：——

  公开号：US8394759B2

  公开（公告）日：2013-03-12
• US8524774B1
  申请人：——

  公开号：US8524774B1

  公开（公告）日：2013-09-03