(E)-N-(4-(4-chlorophenyl)but-3-en-2-yl)-N,4-dimethylbenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-(4-(4-chlorophenyl)but-3-en-2-yl)-N,4-dimethylbenzenesulfonamide
• 英文别名: (E)-N-(4-(4-chlorophenyl)but-3-en-2-yl)-4-methylbenzenesulfonamide；N-[(E)-4-(4-chlorophenyl)but-3-en-2-yl]-4-methylbenzenesulfonamide
• 化学式: C₁₇H₁₈ClNO₂S
• 分子量: 335.854
• InChiKey: CZBANQSYMXRJMZ-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-氯苯基)-3-丁烯-1-醇 、 对甲苯磺酰胺 在 palladium dichloride 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以75%的产率得到(E)-N-(4-(4-chlorophenyl)but-3-en-2-yl)-N,4-dimethylbenzenesulfonamide
  参考文献：
  名称：

  PdCl2-catalyzed hydrosulfonamidation of homo allylic alcohols: an efficient synthesis of allylic sulfonamides

  摘要：

  A new protocol for the palladium chloride-catalyzed direct hydrosulfonamidation of homoallylic alcohols with migration of the double bond is described. This method requires no preactivation of alcohols and the reaction is environmentally benign with water as the only by-product. Various homoallylic alcohols on hydrosulfonamidation with sulfonamides gave the corresponding products in good yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.024

文献信息

• Bismuth-Catalyzed Direct Substitution of the Hydroxy Group in Alcohols with Sulfonamides, Carbamates, and Carboxamides
  作者：Hongbo Qin、Noriyuki Yamagiwa、Shigeki Matsunaga、Masakatsu Shibasaki

  DOI：10.1002/anie.200602909

  日期：2007.1.8
• PdCl2-catalyzed hydrosulfonamidation of homo allylic alcohols: an efficient synthesis of allylic sulfonamides
  作者：B. Sreedhar、V. Ravi、Deepthi Yada

  DOI：10.1016/j.tetlet.2011.01.024

  日期：2011.3

  A new protocol for the palladium chloride-catalyzed direct hydrosulfonamidation of homoallylic alcohols with migration of the double bond is described. This method requires no preactivation of alcohols and the reaction is environmentally benign with water as the only by-product. Various homoallylic alcohols on hydrosulfonamidation with sulfonamides gave the corresponding products in good yields. (C) 2011 Elsevier Ltd. All rights reserved.