4-phenoxyphenyl 2-(2-pyridyloxy)propyl ether

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-phenoxyphenyl 2-(2-pyridyloxy)propyl ether
• 英文别名: (+)-pyriproxyfen；pyriproxyfen；(S)-(+)-2-[1-methyl-2-(4-phenoxyphenoxy)ethoxy]pyridine；2-[(2S)-1-(4-phenoxyphenoxy)propan-2-yl]oxypyridine
• 化学式: C₂₀H₁₉NO₃
• 分子量: 321.376
• InChiKey: NHDHVHZZCFYRSB-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (S)-1-(4-phenoxyphenoxy)propan-2-ol 生成 4-phenoxyphenyl 2-(2-pyridyloxy)propyl ether
  参考文献：
  名称：

  NISHIDA, SUMIO;MATSUO, NORITADA;HATAKOSHI, MAKOTO;KISIDA, HIROSI

  摘要：

  DOI：

文献信息

• [EN] INDAZOLE-AMINOACETONITRILE DERIVATIVES HAVING SPECIAL PESTICIDAL ACTIVITY<br/>[FR] DERIVES D'INDAZOLE-AMINOACETONITRILE PRESENTANT UNE ACTIVITE PESTICIDE SPECIALE
  申请人：NOVARTIS AG

  公开号：WO2003104202A1

  公开（公告）日：2003-12-18

  The invention relates to compounds of the general formula (I), wherein R1, R2, R3, R4, R5, R6, R7, Y and a have the significances given in claim 1, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.

  该发明涉及一般式(I)的化合物，其中R1、R2、R3、R4、R5、R6、R7、Y和a具有权利要求1中给定的含义，并且可选择其对映体。这些活性成分具有有利的杀虫性能。它们特别适用于控制温血动物上的寄生虫。
• Enantiomeric Separations of Pyriproxyfen and its Six Chiral Metabolites by High-Performance Liquid Chromatography
  作者：Chuntao Zhang、Hui Liu、Donghui Liu、Liying Wang、Jing Gao、Zhiqiang Zhou、Peng Wang

  DOI：10.1002/chir.22568

  日期：2016.3

  and Lux Cellulose‐3 under reverse phase using acetonitrile/water as the mobile phase. The retention factors (k) and selectivity factors (α) decreased with increasing temperature, and the separations were better under low temperature in most cases. The work is of significance for the investigation of the environmental behaviors of pyriproxyfen on an enantiomeric level. Chirality 28:245–252, 2016. © 2016

  吡咯氧芬是一种手性杀虫剂，在环境中已鉴定出10种以上的代谢物。在这项工作中，通过高效液相色谱（HPLC）研究了吡吡洛芬及其六种手性代谢物的对映异构体的分离。使用手性色谱柱Chiralpak IA，Chiralpak IB，Chiralpak IC，Chiralcel OD，Chiralcel OD‐RH，Chiralpak AY‐H，Chiralpak AD‐H，Chiracel OJ‐H（（R，R）‐ Whelk-O 1和Lux Cellulose-3。研究了色谱参数（如流动相组成和温度）对分离的影响，并使用旋光检测器鉴定了对映异构体。这些目标的对映体可以在Chiralpak IA，Chiralpak IB，Chiralcel OD，Chiralpak AY-H，或在正常情况下使用Chiracel OJ‐H。Chiralcel OJ‐H的手性分离效果最佳Ñ己烷作为作为改性剂流动相和异丙醇
• Complex catalyst, process for producing the complex catalyst, and process for producing alchohol derivative with the complex catalyst
  申请人：——

  公开号：US20040077487A1

  公开（公告）日：2004-04-22

  There are provided (asymmetric) complex catalysts comprising metal complexes and Lewis acids as components, the metal complex being of formula (1): 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same or different and are independently hydrogen, halogen, alkyl or the like; one of R 9 and R 10 is hydrogen and the other is alkyl of 1 to 4 carbon atoms or the like; Q is a single bond or alkylene of 1 to 4 carbon atoms; M is a metal ion; and A is a balancing counter ion or ligand; processes for the production of these complex catalysts; processes for the production of (optically active) alcohol derivatives, characterized in that cyclic ether compounds are reacted with phenol derivatives in the presence of these complex catalysts; and further processes for producing (optically active) nitrogen-containing heterocyclic compounds by reacting these alcohol derivatives with halogenated nitrogen-containing heterocyclic compounds in the presence of a base.

  提供了由金属配合物和路易斯酸组成的（不对称的）复杂催化剂，其中金属配合物的化学式为（1）：1其中R1、R2、R3、R4、R5、R6、R7和R8相同或不同，独立地是氢、卤素、烷基或类似物；R9和R10中的一个是氢，另一个是1至4个碳原子的烷基或类似物；Q是单键或1至4个碳原子的烷基；M是金属离子；A是平衡的反离子或配体；制备这些复杂催化剂的方法；制备（光学活性的）醇衍生物的方法，其特征在于在这些复杂催化剂的存在下，环氧化合物与酚衍生物反应；以及在碱的存在下，通过将这些醇衍生物与卤素化的含氮杂环化合物反应，制备（光学活性的）含氮杂环化合物的进一步方法。
• Complex catalyst, process for producing the complex catalyst, and process for producing alcohol derivative with the complex catalyst
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06995110B2

  公开（公告）日：2006-02-07

  There are provided (asymmetric) complex catalysts comprising metal complexes and Lewis acids as components, the metal complex being of formula (1): wherein R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and are independently hydrogen, halogen, alkyl or the like; one of R9 and R10 is hydrogen and the other is alkyl of 1 to 4 carbon atoms or the like; Q is a single bond or alkylene of 1 to 4 carbon atoms; M is a metal ion; and A is a balancing counter ion or ligand; processes for the production of these complex catalysts; processes for the production of (optically active) alcohol derivatives, characterized in that cyclic ether compounds are reacted with phenol derivatives in the presence of these complex catalysts; and further processes for producing (optically active) nitrogen-containing heterocyclic compounds by reacting these alcohol derivatives with halogenated nitrogen-containing heterocyclic compounds in the presence of a base.

  提供了（非对称）复杂催化剂，包括金属配合物和路易斯酸作为组分，其中金属配合物的化学式为（1）：其中R1、R2、R3、R4、R5、R6、R7和R8相同或不同，独立地为氢、卤素、烷基或类似物；R9和R10中的一个是氢，另一个是1至4个碳原子的烷基或类似物；Q是单键或1至4个碳原子的烷基；M是金属离子；A是平衡的计数离子或配体；生产这些复杂催化剂的过程；生产（光学活性的）醇衍生物的过程，其特征在于在这些复杂催化剂的存在下，环氧化合物与酚衍生物反应；以及在碱的存在下，通过将这些醇衍生物与卤代氮杂环化合物反应来生产（光学活性的）含氮杂环化合物的进一步过程。
• Nitrogen-containing heterocyclic compounds, and their production and use
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0128648A1

  公开（公告）日：1984-12-19

  A nitrogen-containing heterocyclic compound of the formula: wherein R, is either one of the following groups: (in which R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 and R17 are each independently a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a C1-C4 alkylthio group, a trifluoromethyl group or a nitro group, R18, R19, R20 and R21 are each independently a hydrogen atom or a methyl group, k is 0 or 1 and I is 0 or an integer of 1 to 3); R2 and R3 are each independently a hydrogen atom, a halogen atom or a methyl group; R4 is a halogen atom or a methyl group; Rs and R6 are each independently a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a C1-C4 haloalkyl group or a C1-C4 haloalkoxy group; X, Y and Z are each independently an oxygen atom, a sulfur atom or a methylene group; m is 0 or an integer of 1 to 4; and n is 0 or an integer of 1 or 2, which is useful as an insecticidal agent.

  式中的含氮杂环化合物： 其中 R，是下列基团之一： (其中R7、R8、R9、R10、R11、R12、R13、R14、R15、R16和R17各自独立地为氢原子、卤素原子、C1-C4烷基、C1-C4烷氧基、C1-C4烷硫基、三氟甲基或硝基，R18、R19、R20和R21各自独立地为氢原子或甲基，k为0或1，I为0或1至3的整数）； R2 和 R3 各自独立地为氢原子、卤素原子或甲基； R4 是卤素原子或甲基； Rs 和 R6 各自独立地为氢原子、卤素原子、C1-C4 烷基、C1-C4 烷氧基、C1-C4 卤代烷基或 C1-C4 卤代烷氧基； X、Y 和 Z 各自独立地为氧原子、硫原子或亚甲基； m 是 0 或 1 至 4 的整数；以及 n 为 0 或 1 或 2 的整数，可用作杀虫剂。