(R)-N-(2-benzoylphenyl)-2,2-dimethyl-2-(1-phenyl-ethylamino)-acetamide | 1445869-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-(2-benzoylphenyl)-2,2-dimethyl-2-(1-phenyl-ethylamino)-acetamide
• 英文别名: (R)-N-(2-Benzoylphenyl)-2-methyl-2-((1-phenylethyl)amino)propanamide；N-(2-benzoylphenyl)-2-methyl-2-[[(1R)-1-phenylethyl]amino]propanamide
• CAS: 1445869-56-6
• 化学式: C₂₅H₂₆N₂O₂
• 分子量: 386.494
• InChiKey: JMOYUXKHSRXQPR-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氨基-4,4,4-三氟丁酸 、 (R)-N-(2-benzoylphenyl)-2,2-dimethyl-2-(1-phenyl-ethylamino)-acetamide 、 nickel(II) acetate tetrahydrate 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 以74%的产率得到
  参考文献：
  名称：

  Chemical deracemization and (S) to (R) interconversion of some fluorine-containing α-amino acids

  摘要：

  Several omega-CF3-substituted alpha-amino acids have been prepared in optically pure form via two complementary approaches. Racemic fluorinated derivatives of 2-aminobutanoic acid, norvaline and norleucine were chemically deracemized by complexation with a Ni(II) salt and a chiral reagent derived from alpha-(phenyl)ethylamine. Additionally this procedure also allowed the conversion of readily available L-amino acids, CF3-analogs of cysteine and methionine, into the corresponding unnatural D-series. Optically pure amino acids are obtained upon disassembly of the Ni(II) complexes with recovery of the chiral ligand. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.02.022
• 作为产物：
  描述：

  N-(2-benzoyl-phenyl)-2-bromo-2-methylpropanamide 、 R(+)-alpha-甲基苄胺 以 乙腈 为溶剂， 反应 24.0h， 以100%的产率得到(R)-N-(2-benzoylphenyl)-2,2-dimethyl-2-(1-phenyl-ethylamino)-acetamide
  参考文献：
  名称：

  Soloshonok, Vadim A.; Ellis, Trevor K.; Ueki, Hisanori, Journal of the American Chemical Society, 2009, vol. 131, p. 7208 - 7209

  摘要：

  DOI：

文献信息

• Soloshonok, Vadim A.; Ellis, Trevor K.; Ueki, Hisanori, Journal of the American Chemical Society, 2009, vol. 131, p. 7208 - 7209
  作者：Soloshonok, Vadim A.、Ellis, Trevor K.、Ueki, Hisanori、Ono, Taizo

  DOI：——

  日期：——
• Chemical deracemization and (S) to (R) interconversion of some fluorine-containing α-amino acids
  作者：Alexander E. Sorochinsky、Hisanori Ueki、José Luis Aceña、Trevor K. Ellis、Hiroki Moriwaki、Tatsunori Sato、Vadim A. Soloshonok

  DOI：10.1016/j.jfluchem.2013.02.022

  日期：2013.8

  Several omega-CF3-substituted alpha-amino acids have been prepared in optically pure form via two complementary approaches. Racemic fluorinated derivatives of 2-aminobutanoic acid, norvaline and norleucine were chemically deracemized by complexation with a Ni(II) salt and a chiral reagent derived from alpha-(phenyl)ethylamine. Additionally this procedure also allowed the conversion of readily available L-amino acids, CF3-analogs of cysteine and methionine, into the corresponding unnatural D-series. Optically pure amino acids are obtained upon disassembly of the Ni(II) complexes with recovery of the chiral ligand. (C) 2013 Elsevier B.V. All rights reserved.