The patent describes homo- or hetero-bifunctional derivatives of polyethylene glycol (PEG) obtained by selectively modifying the hydroxyl end groups of commercial PEGs of different molecular weights with reactive bifunctional molecules. The synthesis process comprises steps involving sequential derivatization of PEG terminal hydroxyl groups with a bifunctional compound, purification of the bifunctional PEG obtained and/or protection of its functional groups with possible selective removal of terminal protections. The bifunctional PEGs (biPEG) obtained are usable as carriers and/or stabilizers for substances used for diagnostic, prophylactic and therapeutic purposes, conjugated to the same biocompatible biPEG support. The bifunctionalized PEG derivatives can also be used in supported synthesis processes.
该专利描述了通过选择性地用反应性双官能分子修改不同分子量的商业聚
乙二醇(P
EG)的羟基末端基团而获得的聚
乙二醇(P
EG)的同源或异源双功能衍
生物。合成过程包括涉及将P
EG末端羟基基团顺序衍生化为双功能化合物的步骤,纯化所得的双功能P
EG和/或保护其功能基团,可能选择性地去除末端保护。所获得的双功能P
EG(biP
EG)可用作用于诊断、预防和治疗目的的物质的载体和/或稳定剂,与相同的
生物相容性biP
EG支持结合。双功能化的P
EG衍
生物还可用于支持合成过程中。