2-甲基-2-苯基噻唑烷 | 770-86-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-甲基-2-苯基噻唑烷
• 英文名称: 2-methyl-2-phenylthiazolidine
• 英文别名: 2-methyl-2-phenyl-thiazolidine；2-Methyl-2-phenyl-thiazolidin；(+/-)-2-Methyl-2-phenyl-thiazolidin；2-Phenyl-2-methyl-thiazolidin；2-methyl-2-phenyl-1,3-thiazolidine
• CAS: 770-86-5
• 化学式: C₁₀H₁₃NS
• 分子量: 179.286
• InChiKey: XJJXLHLQVUIRFW-UHFFFAOYSA-N

物化性质

• 沸点：
  113-115 °C(Press: 3 Torr)
• 密度：
  1.074±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-甲基-2-苯基噻唑烷 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N-<α-Methyl-benzyl>-2-mercapto-aethylamin
  参考文献：
  名称：

  Eliel,E.L. et al., Journal of Organic Chemistry, 1962, vol. 27, p. 4712 - 4713

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-半胱氨酸 、 苯乙酮 生成 2-甲基-2-苯基噻唑烷
  参考文献：
  名称：

  希夫碱。第二部分 在酮存在下通过α-氨基酸脱羧制备的一些酮亚胺及其与醛亚胺与异氰酸苯酯的反应

  摘要：

  描述了通过在芳族酮的存在下氨基酸热脱羧或直接从相应的胺进行的氨基酸制备的一些酮亚胺。在β-羟基胺的情况下，发生闭环以产生恶唑烷。衍生自邻羟基苯乙酮的芳香酮亚胺与异氰酸苯酯反应生成香豆素衍生物。由邻，对羟基和对甲氧基取代的苯甲醛制得的醛亚胺与异氰酸苯酯反应，生成β-三嗪衍生物。

  DOI：

  10.1039/j39680000411

文献信息

• Phenyliodine(III) Diacetate/I ₂ ‐Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4‐Thiazines by a One‐Pot Morin Rearrangement of N,S <i>‐</i> Acetals
  作者：Fanny Danton、Mohamed Othman、Ata Martin Lawson、Ján Moncol、Alina Ghinet、Benoît Rigo、Adam Daïch

  DOI：10.1002/chem.201901111

  日期：2019.4.26

  diacetate (PIDA)/I2 combination towards Morin 1,4‐thiazine compounds has been developed starting from N,S‐acetals. The latter leads to “one‐step” regioselective methylene insertion without the need for traditional sulfoxide intermediates in good yields. The reaction involves easily accessible N,S‐acetals obtained from cost‐effective basic ketones and cysteamine as starting materials. This process ultimately

  使用phenyliodine（III）二乙酸酯（PIDA）/ I的高效多米诺变换2组合朝向莫林1,4-噻嗪化合物已经开发选自N，S开始-缩醛。后者导致“一步式”区域选择性亚甲基插入，而无需以高收率使用传统的亚砜中间体。该反应涉及方便N，S -从成本效益的基本酮和半胱胺获得作为原料缩醛。此过程最终导致与1,4-噻嗪有关的天然产物和进一步的QSAR研究所需的熔融衍生物。
• CATALYST FOR BISPHENOL COMPOUND PRODUCTION AND PROCESS FOR PRODUCING BISPHENOL COMPOUND WITH THE CATALYST
  申请人：——

  公开号：US20040127753A1

  公开（公告）日：2004-07-01

  Provided are a catalyst of high activity and good heavy substance resistance and alcohol resistance for production of bisphenols, and a method for producing bisphenols with the catalyst. The catalyst is a sulfonic acid-type cation-exchange resin modified with (a) a pyridinealkanethiol and (b) an aminoalkanethiol and/or a thiazolidine; and the method comprises reacting a phenol and a ketone in the presence of the catalyst for producing bisphenols.

  提供了一种高活性、良好的重质物抗性和酒精抗性的催化剂，用于生产双酚，以及使用该催化剂生产双酚的方法。该催化剂是一种磺酸型阳离子交换树脂，经修饰后包括(a)吡啶烷硫醇和(b)氨基烷硫醇和/或噻唑烷；该方法包括在催化剂的存在下，将酚和酮反应以生产双酚。
• PROCESS FOR PRODUCING BISPHENOL A
  申请人：IDEMITSU PETROCHEMICAL CO., LTD.

  公开号：EP1160229A1

  公开（公告）日：2001-12-05

  The present invention provides a process for producing bisphenol A which is capable of prolonging the life of an acid-type ion exchange resin partially modified with a sulfur-containing amine compound as catalyst, and increasing the yield of bisphenol A per unit quantity of the catalyst. There is disclosed a process for producing bisphenol A by reacting acetone with phenol in the presence of an acid-type ion exchange resin partially modified with a sulfur-containing amine compound as catalyst and alkylmercaptan as co-catalyst, said process comprising: conducting said reaction using a multi-stage reaction apparatus comprising at least two individual reactors connected in series to each other, wherein the molar ratio of total alkylmercaptan to total acetone and the molar ratio of total acetone to phenol are increased as the conversion rate of the phenol is decreased.

  本发明提供了一种生产双酚 A 的工艺，该工艺能够延长用含硫胺化合物部分改性的酸 型离子交换树脂作为催化剂的寿命，并提高单位数量催化剂的双酚 A 产量。本发明公开了一种生产双酚 A 的工艺，该工艺通过丙酮与苯酚在部分改性为含 硫胺化合物的酸性离子交换树脂作为催化剂和烷基硫醇作为助催化剂的存在下发 生反应来生产双酚 A，所述工艺包括： 1： 使用多级反应装置进行上述反应，该装置由至少两个相互串联的独立反应器组成，其中总烷基硫醇与总丙酮的摩尔比以及总丙酮与苯酚的摩尔比随着苯酚转化率的降低而增加。
• Method for preparing bisphenol in the presence of a modified acidic ion-exchange resin
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1908519A1

  公开（公告）日：2008-04-09

  The present invention provides the use of an ion-exchange resin catalyst, as a catalyst for preparing bisphenol from phenol compounds and ketone, which has a higher selectivity to bisphenol and a longer life time, as compared to a conventional ion-exchange resin, and a method for preparing the same. The present invention also provides a method for preparing bisphenol comprising reacting phenol compounds with ketone, wherein the modified acidic ion-exchange resin in which at least one kind of cationic compound selected from the following (b), (c) and (d) ionically binds to an acidic functional group, is used as a catalyst: (b) a quaternary ammonium ion, (c) a bis(phosphoranylidene) ammonium ion, and (d) an N-substituted nitrogen-containing aromatic cation.

  本发明提供了一种离子交换树脂催化剂的用途，作为从苯酚化合物和酮制备双酚的催化剂，与传统的离子交换树脂相比，该催化剂对双酚具有更高的选择性和更长的使用寿命，并提供了制备该催化剂的方法。 本发明还提供了一种制备双酚的方法，包括使苯酚化合物与酮反应，其中改性酸性离子交换树脂用作催化剂，该树脂中至少有一种阳离子化合物与酸性官能团离子结合，这些阳离子化合物选自以下(b)、(c)和(d)：(b)季铵离子、(c)双(亚磷酰)铵离子和(d)N-取代的含氮芳香阳离子。
• PROCESS FOR PRODUCTION OF BISPHENOL A AND METHOD FOR JUDGMENT OF ION-EXCHANGE RESIN
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：EP1939164A1

  公开（公告）日：2008-07-02

  A process for the production of bisphenol A by condensing phenol with acetone in the presence of a strongly acidic ion-exchange resin, wherein an ion-exchange resin is judged to be a high-quality strongly acidic ion-exchange resin when three times as much deionized water at 25°C as ion-exchange resin is passed through the ion-exchange resin at an LHSV (liquid hour space velocity) of 1.0 hr-1 to give an effluent exhibiting a pH of 5 or above at 25°C, and only such a high-quality strongly acidic ion-exchange resin is selected and used in the above production. According to the invention, a high-quality strongly acidic ion-exchange resin free from the eluation of residual sulfonic acid can be easily selected in the production of bisphenol A, which leads to stable production of bisphenol A with outstanding color tone. Further, the water consumption in washing a catalyst prior to the production of bisphenol A can be reduced, which leads to a lower wastewater disposal cost and stable long-period use of a catalyst.

  一种在强酸性离子交换树脂存在下通过苯酚与丙酮缩合生产双酚 A 的工艺，其中，当离子交换树脂在 25°C 下以三倍于离子交换树脂的去离子水通过离子交换树脂时，判断该离子交换树脂为优质强酸性离子交换树脂，离子交换树脂的 LHSV（液体小时空间速度）为 1.0 hr-1的速度通过离子交换树脂时，流出物在25°C时的pH值为5或以上，在上述生产中只选择和使用这种高质量的强酸性离子交换树脂。根据本发明，在生产双酚 A 的过程中，可以很容易地选择不含残留磺酸洗脱的优质强酸性离子交换树脂，从而稳定地生产出色调出众的双酚 A。此外，还可减少双酚 A 生产前清洗催化剂的耗水量，从而降低废水处理成本，实现催化剂的长期稳定使用。