VUF9034

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: VUF9034
• 英文别名: 1-methyl-N-(5,5-diphenyl-4-pentenyl)-2-phenylethylamine；5,5-diphenyl-N-(1-phenylpropan-2-yl)pent-4-en-1-amine
• 化学式: C₂₆H₂₉N
• 分子量: 355.523
• InChiKey: SQOIYXQKYBKVTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5,5-diphenyl-4-pentenyl bromide 、 非那明 在 potassium carbonate 作用下， 以 various solvent(s) 为溶剂， 反应 96.0h， 生成 VUF9034
  参考文献：
  名称：

  New prenylamine-analogues: investigations of their influence on calcium-dependent biological systems

  摘要：

  Chemically, prenylamine belongs to the diphenylalkylamine class. Compounds of this class are calcium antagonists with a broad spectrum of activities due to their influence on both extracellular and intracellular sites. In the present study the calcium antagonistic profile of a recently developed new series of prenylamine analogues has been investigated using different in vitro systems. The inhibiting concentrations for the most active compound are almost-equal-to 1.5 muM; several derivatives are inactive up to a concentration of 10 muM. Structural modifications towards an increase of lipophilicity make these molecules interact (inhibition) with the intracellular calcium-binding protein calmodulin; for the series no correlation between calcium-blocking and calmodulin antagonistic effects has been found.

  DOI：

  10.1016/0223-5234(93)90086-t