cis-1,2-Epoxy-p-menth-8-en

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: cis-1,2-Epoxy-p-menth-8-en
• 英文别名: cis-limonene-1,2-epoxide；(1S,6R)-1-methyl-4-prop-1-en-2-yl-7-oxabicyclo[4.1.0]heptane
• 化学式: C₁₀H₁₆O
• 分子量: 152.236
• InChiKey: CCEFMUBVSUDRLG-XVBQNVSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cis-1,2-Epoxy-p-menth-8-en 、 2-氨基苯酚 在 zinc dipicolinate 作用下， 生成 2-[[(4R)-2-hydroxy-1-methyl-4-prop-1-en-2-ylcyclohexyl]amino]phenol
  参考文献：
  名称：

  CATALYST SYSTEM

  摘要：

  Proposed is a catalyst system specifically for the rearrangement of epoxides into allyl alcohols comprising or consisting of (a) a salt of formula (I) XY (I) in which X represents Zn 2+ and/or Co 2+ and Y represents an anion selected from the group formed from laurate, palmitate, stearate, picolinate, glycinate, gluconate, naphthenate, 2-hexyldecanoate, 2-octyldodecanoate, cyclohexane butyrate and mixtures thereof, and (b) at least one aminophenol.

  公开号：

  US20240051907A1
• 作为产物：
  描述：

  limonene. 在 Mn(N-(4-carboxybenzyl)iminodiacetic acid(-2H))(H₂O) 、 ammonium acetate 、 双氧水 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 6.0h， 生成 cis-1,2-Epoxy-p-menth-8-en 、 1-甲基-4-(1-甲基乙烯基)环己醇
  参考文献：
  名称：

  Synthesis, Characterization, Magnetic and Catalytic Properties of a Ladder‐Shaped Mn ^II Coordination Polymer

  摘要：

  Abstract[Mn(LH)(H2O)]n {1, where LH2– is the dianion of N‐(4‐carboxybenzyl)iminodiacetic acid} has been synthesized and its crystal structure has been determined. The crystal of 1 is built from 1D polymeric ladder‐shaped chains that extend to a 3D supramolecular architecture through H‐bonds. The compound was characterized with spectroscopic and physicochemical techniques. Variable‐temperature magnetic data suggest that there are weak antiferromagnetic interactions. Compound 1 has been evaluated as a heterogeneous oxidation catalyst. It catalyzes alkene epoxidation selectively in relatively high yields.

  DOI：

  10.1002/ejic.201402419

文献信息

• Activation of Hydrogen Peroxide through Hydrogen-Bonding Interaction with Acidic Alcohols:  Epoxidation of Alkenes in Phenol
  作者：Joos Wahlen、Dirk E. De Vos、Pierre A. Jacobs

  DOI：10.1021/ol0344422

  日期：2003.5.1

  text] Electrophilic activation of hydrogen peroxide can be achieved in acidic alcohol solvents without the need for a metal catalyst. This concept is illustrated by the epoxidation of alkenes with H(2)O(2) employing phenol as a solvent. It is proposed that intermolecular hydrogen bonding between H(2)O(2) and phenol activates H(2)O(2) for oxygen-atom transfer. In this interaction, the role of phenol

  [反应：见正文]在酸性醇溶剂中无需金属催化剂即可实现过氧化氢的亲电活化。用苯酚作为溶剂，用H（2）O（2）对烯烃进行环氧化，可以说明这一概念。建议在H（2）O（2）和苯酚之间的分子间氢键激活H（2）O（2）进行氧原子转移。在这种相互作用中，苯酚的作用是纯粹的催化作用。
• METHOD FOR TREATING OCULAR DEMODEX
  申请人：Gao Ying-Ying

  公开号：US20090214676A1

  公开（公告）日：2009-08-27

  The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex -induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a composition comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; (+)-Carvone; alpha-Terpineol; Cardinene; d-Carvone; l-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Cimene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.
• Method for Treating Ocular Demodex
  申请人：Gao Ying-Ying

  公开号：US20120004320A1

  公开（公告）日：2012-01-05

  The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex -induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a composition comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; Carvone; alpha-Terpineol; Cardinene; d-Carvone; l-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Cimene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.
• US7851660B1
  申请人：——

  公开号：US7851660B1

  公开（公告）日：2010-12-14
• US7884252B1
  申请人：——

  公开号：US7884252B1

  公开（公告）日：2011-02-08