(4,8-di-tert-butyl-2,10-dimethyl-12H-5,7-dioxa-6-phosphadibenzo[a,d]cycloocten-6-yl)dimethylamine

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: (4,8-di-tert-butyl-2,10-dimethyl-12H-5,7-dioxa-6-phosphadibenzo[a,d]cycloocten-6-yl)dimethylamine
• 英文别名: 1,9-ditert-butyl-N,N,3,7-tetramethyl-5H-benzo[d][1,3,2]benzodioxaphosphocin-11-amine
• 化学式: C₂₅H₃₆NO₂P
• 分子量: 413.54
• InChiKey: IISDBADSIROZSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  四氯邻苯二酚 、 (4,8-di-tert-butyl-2,10-dimethyl-12H-5,7-dioxa-6-phosphadibenzo[a,d]cycloocten-6-yl)dimethylamine 反应 0.5h， 生成 1',9'-ditert-butyl-4,5,6,7-tetrachloro-N,N,3',7'-tetramethylspiro[1,3,2lambda5-benzodioxaphosphole-2,11'-5H-benzo[d][1,3,2]benzodioxaphosphocine]-2-amine
  参考文献：
  名称：

  带有八元环的螺正膦立体异构体的表征：对三角双锥体磷的亲脂性的影响

  摘要：

  DOI：

  10.1021/ja992304v
• 作为产物：
  描述：

  六甲基磷酰三胺 、 2,2'-亚甲基双-(4-甲基-6-叔丁基苯酚) 以 甲苯 为溶剂， 以90%的产率得到(4,8-di-tert-butyl-2,10-dimethyl-12H-5,7-dioxa-6-phosphadibenzo[a,d]cycloocten-6-yl)dimethylamine
  参考文献：
  名称：

  Chirality Control of Tropos Diphenylmethane-Derived Phosphoramidites by Chiral Dienes: Its Application to Asymmetric Michael Addition

  摘要：

  The Rh complex of tropos diphenylmethane-derived phosphoramidite could be chirally controlled to adopt single chiral conformation upon addition of a chiral diene. In the asymmetric Michael addition of alpha-cyanocarboxylates catalyzed by the Rh complexes, the chiral diene and bisphenylmethane-derived phosphoramidite functioned to attain higher enantioselectivity and catalytic activity via asymmetric activation.

  DOI：

  10.3987/com-08-s(f)102
• 作为试剂：
  描述：

  2-甲基-2-丙基2-氰基丙烷酸酯 、 丙烯醛 在 C₃₈H₄₈Cl₂O₂Rh₂ 、 N,N-二异丙基乙胺 、 (4,8-di-tert-butyl-2,10-dimethyl-12H-5,7-dioxa-6-phosphadibenzo[a,d]cycloocten-6-yl)dimethylamine 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-2-cyano-2-methyl-5-oxopentanoic acid tert-butyl ester 、 (R)-2-cyano-2-methyl-5-oxopentanoic acid tert-butyl ester
  参考文献：
  名称：

  Chirality Control of Tropos Diphenylmethane-Derived Phosphoramidites by Chiral Dienes: Its Application to Asymmetric Michael Addition

  摘要：

  The Rh complex of tropos diphenylmethane-derived phosphoramidite could be chirally controlled to adopt single chiral conformation upon addition of a chiral diene. In the asymmetric Michael addition of alpha-cyanocarboxylates catalyzed by the Rh complexes, the chiral diene and bisphenylmethane-derived phosphoramidite functioned to attain higher enantioselectivity and catalytic activity via asymmetric activation.

  DOI：

  10.3987/com-08-s(f)102

文献信息

• Chirality Control of Tropos Diphenylmethane-Derived Phosphoramidites by Chiral Dienes: Its Application to Asymmetric Michael Addition
  作者：Koichi Mikami、Kazuki Wakabayashi、Kohsuke Aikawa

  DOI：10.3987/com-08-s(f)102

  日期：——

  The Rh complex of tropos diphenylmethane-derived phosphoramidite could be chirally controlled to adopt single chiral conformation upon addition of a chiral diene. In the asymmetric Michael addition of alpha-cyanocarboxylates catalyzed by the Rh complexes, the chiral diene and bisphenylmethane-derived phosphoramidite functioned to attain higher enantioselectivity and catalytic activity via asymmetric activation.
• Characterization of Stereoisomers of Spirophosphoranes Bearing an Eight-Membered Ring:  Implications on Apicophilicity in Trigonal Bipyramidal Phosphorus
  作者：Sudha Kumaraswamy、C. Muthiah、K. C. Kumara Swamy

  DOI：10.1021/ja992304v

  日期：2000.2.1