[3-(5,5-dioxo-5H-5λ⁶-phenothiazin-10-yl)-propyl]-dimethyl-amine | 26928-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: [3-(5,5-dioxo-5H-5λ⁶-phenothiazin-10-yl)-propyl]-dimethyl-amine
• 英文别名: Promazin-5,5-dioxid；3-(5,5-dioxophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
• CAS: 26928-73-4
• 化学式: C₁₇H₂₀N₂O₂S
• 分子量: 316.424
• InChiKey: SCOQPZJZRQJDSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  49
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [3-(5,5-dioxo-5H-5λ⁶-phenothiazin-10-yl)-propyl]-dimethyl-amine 在 双氧水 作用下， 生成 Promazin-5,5-dioxid-N-oxid
  参考文献：
  名称：

  Gasco; Aruga, Farmaco, Edizione Scientifica, 1970, vol. 25, # 2, p. 112 - 117

  摘要：

  DOI：
• 作为产物：
  描述：

  10H-吩噻嗪 5,5-二氧化物 、 N,N-二甲基-3-氯丙胺 在 四丁基硫酸氢铵 氢氧化钾 、 potassium carbonate 作用下， 生成 [3-(5,5-dioxo-5H-5λ⁶-phenothiazin-10-yl)-propyl]-dimethyl-amine
  参考文献：
  名称：

  N-Dimethylaminopropylation in a Solid-Liquid Two Phase System: Synthesis of Chlorpromazine, its Analogs, and Related Compounds

  摘要：

  DOI：

  10.1055/s-1984-30719

文献信息

• COMPLEX OF ORGANIC MEDICINES AND BETA-CYCLODEXTRIN DERIVATIVES AND ITS PREPARING PROCESS
  申请人：Liu, Yunqing

  公开号：EP1514877A1

  公开（公告）日：2005-03-16

  The present invention relates to a process of preparing a water-soluble complex of water-insoluble or sparingly-soluble organic medicines and beta-cyclodextrin derivatives: a. dissolving successively or simultaneously the organic medicines and the beta-cyclodextrin derivatives in organic solvent(s) at certain mole ratio or mass ratio in the presence of suitable amount of water; b. removing the organic solvent from the solution of the step a to obtain aqueous solution of the organic medicine and beta-cyclodextrin derivative; and c. removing water from the aqueous solution to obtain the complex of the organic medicine and beta-cyclodextrin derivative. The invention also provides a sterile water-soluble complex of water-insoluble or sparingly-soluble organic medicines and beta-cyclodextrin derivatives. A fully-water-soluble complex can be prepared from any water-insoluble or sparingly-soluble organic medicines or other organic compounds according to the present invention. Thus, appreciably convenient means are provided for industrial uses of such organic medicine preparations and of other organic compounds.

  本发明涉及一种制备不溶于水或难溶于水的有机药物和 β-环糊精衍生物的水溶性复合物的工艺： a. 在适量水的存在下，以一定的摩尔比或质量比将有机药物和 β-环糊精衍生物先后或同时溶解在有机溶剂中； b. 从步骤 a 的溶液中除去有机溶剂，得到有机药物和 β-环糊精衍生物的水溶液；以及 c. 从水溶液中除去水，得到有机药物和 β-环糊精衍生物的复合物。从步骤 a 的溶液中除去有机溶剂，得到有机药物和 β-环糊精衍生物的水溶液；以及 c. 从水溶液中除去水，得到有机药物和 β-环糊精衍生物的复合物。本发明还提供了不溶于水或少溶于水的有机药物和 β-环糊精衍生物的无菌水溶性复合物。根据本发明，可以用任何不溶于水或难溶于水的有机药物或其他有机化合物制备全水溶性复合物。因此，本发明为此类有机药物制剂和其他有机化合物的工业用途提供了非常方便的方法。
• Embelia concinna extract comprising flavonoids in cosmetic and pharmaceutical compositions
  申请人：Bayer Consumer Care AG

  公开号：EP2649987A1

  公开（公告）日：2013-10-16

  The present invention deals with an Embelia extract - preferably an extract from Embelia concinna titrated in flavonoids - , its process for preparation and its use in a cosmetical or pharmaceutical composition for the treatment of skin sensitivity, for the treatment of allergic reactions of the skin, for soothing and for the treatment of itching skin and for the regulation of inflammatory drifts in the skin.

  本发明涉及一种恩贝藻提取物--最好是从含黄酮类滴定物的恩贝藻中提取的提取物--的制备方法及其在化妆品或药物组合物中的用途，用于治疗皮肤敏感、皮肤过敏反应、舒缓和治疗皮肤瘙痒以及调节皮肤炎症反应。
• COMPOSITION FOR ENHANCING INDUCTION OF HUMORAL IMMUNITY, AND VACCINE PHARMACEUTICAL COMPOSITION
  申请人：Nitto Denko Corporation

  公开号：EP3178491A1

  公开（公告）日：2017-06-14

  The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

  本发明旨在提供一种促进体液免疫诱导的组合物和一种疫苗药物组合物，该组合物可普遍用于各种抗原的体液免疫诱导抗原，含有Th2反应促进剂，并能发挥较高的体液免疫诱导效果。本发明涉及一种疫苗药物组合物，它含有用于诱导体液免疫的抗原和至少一种 Th2 反应促进剂。
• Composition for enhancing induction of humoral immunity, and vaccine pharmaceutical composition
  申请人：NITTO DENKO CORPORATION

  公开号：US10369219B2

  公开（公告）日：2019-08-06

  The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

  本发明旨在提供一种促进体液免疫诱导的组合物和一种疫苗药物组合物，该组合物可普遍用于各种抗原的体液免疫诱导抗原，含有Th2反应促进剂，并能发挥较高的体液免疫诱导效果。本发明涉及一种疫苗药物组合物，它含有用于诱导体液免疫的抗原和至少一种 Th2 反应促进剂。
• Complex of organic medicines and beta-cyclodextrin derivatives and its preparing process
  申请人：Liu Yunqing

  公开号：US20050215520A1

  公开（公告）日：2005-09-29

  The present invention relates to a process of preparing a water-soluble complex of water-insoluble or sparingly-soluble organic medicines and beta-cyclodextrin derivatives: a. dissolving successively or simultaneously the organic medicines and the beta-cyclodextrin derivatives in organic solvent(s) at certain mole ratio or mass ratio in the presence of suitable amount of water; b. removing the organic solvent from the solution of the step a to obtain aqueous solution of the organic medicine and beta-cyclodextrin derivative; and c. removing water from the aqueous solution to obtain the complex of the organic medicine and beta-cyclodextrin derivative. The invention also provides a sterile water-soluble complex of water-insoluble or sparingly-soluble organic medicines and beta-cyclodextrin derivatives. A fully-water-soluble complex can be prepared from any water-insoluble or sparingly-soluble organic medicines or other organic compounds according to the present invention. Thus, appreciably convenient means are provided for industrial uses of such organic medicine preparations and of other organic compounds.

  本发明涉及一种制备不溶于水或难溶于水的有机药物和 β-环糊精衍生物的水溶性复合物的工艺： a. 在适量水的存在下，以一定的摩尔比或质量比将有机药物和 β-环糊精衍生物先后或同时溶解在有机溶剂中； b. 从步骤 a 的溶液中除去有机溶剂，得到有机药物和 β-环糊精衍生物的水溶液；以及 c. 从水溶液中除去水，得到有机药物和 β-环糊精衍生物的复合物。从步骤 a 的溶液中除去有机溶剂，得到有机药物和 β-环糊精衍生物的水溶液；以及 c. 从水溶液中除去水，得到有机药物和 β-环糊精衍生物的复合物。本发明还提供了不溶于水或少溶于水的有机药物和 β-环糊精衍生物的无菌水溶性复合物。根据本发明，可以用任何不溶于水或难溶于水的有机药物或其他有机化合物制备全水溶性复合物。因此，本发明为此类有机药物制剂和其他有机化合物的工业用途提供了非常方便的方法。