[EN] 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF<br/>[FR] 19-NOR-STÉROÏDES NEUROACTIFS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
申请人:SAGE THERAPEUTICS INC
公开号:WO2014169836A1
公开(公告)日:2014-10-23
Provided herein are 3,3-disubstituted19-nor-steroidal compounds according to Formula(I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions,for example, treatment of sleep disorders, mood disorders,schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders,personality disorders,autism spectrum disorders, pain,traumatic brain injury, vascular diseases,substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.
Conformation of ring A in some 2β-methyl- and 2β-acetoxy-19-nortestosterones
作者:Y. Yamato、H. Kaneko
DOI:10.1016/s0040-4020(01)93905-5
日期:1965.1
2β-methyl-19-norsteroids are described. By means of optical rotatory dispersion and NMR spectroscopy it is shown that the introduction of 2β-methyl and 2β-acetoxy substituents into 19-nortestosterones changes the normal half chair conformational of A ring to a twist form as cited in the cholestane series.
19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF
申请人:SAGE THERAPEUTICS, INC.
公开号:US20170246191A1
公开(公告)日:2017-08-31
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I):
and pharmaceutically acceptable salts thereof; wherein
, R
1
, R
2
, R
3a
, R
3b
, R
4a
, R
4b
, R
5
, R
6
, and R
7
are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
[EN] 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF<br/>[FR] 19-NOR-C21-N-PYRAZOLYL-STÉROÏDES C3,3-DISUBSTITUÉS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
申请人:SAGE THERAPEUTICS INC
公开号:WO2014169833A9
公开(公告)日:2016-03-03
19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF
申请人:SAGE THERAPEUTICS, INC.
公开号:US20170233432A1
公开(公告)日:2017-08-17
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I):
and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.