5,15-Bis(4-fluoro-3-methylphenyl)-10,20-bis(4-methoxyphenyl)porphyrin | 132313-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 5,15-Bis(4-fluoro-3-methylphenyl)-10,20-bis(4-methoxyphenyl)porphyrin
• CAS: 132313-40-7
• 化学式: C₄₈H₃₆F₂N₄O₂
• 分子量: 738.836
• InChiKey: JGEGDRMXQSEAKN-UDTYQVGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.24
• 重原子数：
  56.0
• 可旋转键数：
  6.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  75.82
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  4-Fluoro-3-methylphenylmagnesium bromide 在 lithium aluminium tetrahydride 作用下， 以 溶剂黄146 、 丙酸 为溶剂， 生成 5,15-Bis(4-fluoro-3-methylphenyl)-10,20-bis(4-methoxyphenyl)porphyrin
  参考文献：
  名称：

  Stepwise syntheses of unsymmetrical tetra-arylporphyrins. Adaptation of the macdonald dipyrrole self-condensation methodology

  摘要：

  DOI：

  10.1016/s0040-4039(00)88540-8

文献信息

• Rational tetraarylporphyrin syntheses: tetraarylporphyrins from the MacDonald route
  作者：David M. Wallace、Sam H. Leung、Mathias O. Senge、Kevin M. Smith

  DOI：10.1021/jo00077a056

  日期：1993.12

  Four new synthetic routes to meso-tetraarylporphyrins using a MacDonald-type 2 + 2 condensation are described. Self-condensation of a 5-aryldipyrromethane (e.g., 17) with an aryl-substituted one-carbon bridging unit affords a mixture of tetraarylporphyrins due to acid-catalyzed redistribution reactions. The second and third methods presented here show wide applicability for the preparation of 5,10,15,20-tetraaryl-substituted porphyrins (e.g., 31, 37, 48, 49) with 2-fold rotational symmetry and involve self-condensation of 5-aryl-1-aryldipyrromethanecarbinols. Finally, the fourth approach involves a 2 + 2 approach in which one of the two dipyrromethanes bears both of the bridging carbons in the porphyrin products, affording porphyrin 50 which possesses three different aryl rings, with one pair of uniquely opposite identical aryl groups. The last two 2 + 2 methods are further extended to give a tetraarylporphyrin 38 bearing four different aryl groups in a predesignated array, the structure of which is confirmed by a single-crystal X-ray study.
• Sickled Erythrocytes with Anti-tumor Agents Induce Tumor Vaso-occlusion and Tumoricidal Effects
  申请人：Terman David S.

  公开号：US20120195869A1

  公开（公告）日：2012-08-02

  The present invention provides erythrocytes or nucleated erythrocyte precursors from animals or patients with at least one S hemoglobin allele which are capable of selectively localizing in tumor vasculature resulting in vaso-occlusion, hemolysis and heme release. A tumoricidal effect is achieved when these cells are administered in before during or after administration of (i) an agent(s) that interferes with degradation of reactive oxygen species, (ii) impairs glucose uptake and/or (iii) chemotherapy. These cells also carry oncolytic viruses, antitumor proteins, multidrug resistant proteins, chemotherapy, monoclonal antibodies, superantigens, superantigen conjugates and fusion proteins, siRNAs, plasmids and non-protein toxins and attenuated tumoricidal bacterial cells specifically into the tumors and induce a tumoricidal effect.
• US8431117B2
  申请人：——

  公开号：US8431117B2

  公开（公告）日：2013-04-30