乙二胺 | 6780-13-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 乙二胺
• 中文别名: 一水合-1,2-二氨基乙烷；乙二胺单水合物；乙二胺水合物；乙二胺,一水；乙二胺(一水合)；一水合乙二胺；乙二胺一水合物；水合乙二胺；乙二胺一水
• 英文名称: 1,2-ethanediamine monohydrate
• 英文别名: ethylenediamine monohydrate；1,2-Diaminoethan-hydrat；1,2-Diaminoethan-Monohydrat；1,2-Diaminoethan Monohydrate；1,2-diaminoethane mohohydrate；Aethylendiamin; Monohydrat；1,2-diaminoethane hydrate；ethylenediamine hydrate；ethylenediamine*H2O；ethane-1,2-diamine;hydrate
• CAS: 6780-13-8
• 化学式: C₂H₈N₂*H₂O
• 分子量: 78.1142
• InChiKey: XZUAPPXGIFNDRA-UHFFFAOYSA-N

物化性质

• 熔点：
  10 °C
• 沸点：
  118 °C
• 密度：
  0,96 g/cm3
• 闪点：
  34°C

计算性质

• 辛醇/水分配系数(LogP)：
  -1.92
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  53
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险等级：
  8/3
• 安全说明：
  S16,S23,S26,S36/37/39,S45
• 危险类别码：
  R10
• 海关编码：
  2921199090
• 危险品运输编号：
  1604
• 储存条件：
  存放于惰性气体中，以避免与空气接触。

SDS

Ethylenediamine Monohydrate
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Ethylenediamine Monohydrate

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS
Category 3
Flammable liquids
HEALTH HAZARDS
Category 4
Acute toxicity (Oral)
Acute toxicity (Dermal) Category 3
Category 1B
Skin corrosion/irritation
Serious eye damage/eye irritation Category 1
Category 1
Respiratory sensitization
Skin sensitization Category 1
Blood system, Respiratory system, Kidney
Specific target organ toxicity
- Single exposure [Category 1]
Liver, Visual system, Kidney
Specific target organ toxicity
- Repeated exposure [Category 2]
ENVIRONMENTAL HAZARDS
Acute aquatic hazard Category 2
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Danger
Signal word
Hazard statements Flammable liquid and vapour
Harmful if swallowed
Toxic in contact with skin
Causes severe skin burns and eye damage
May cause allergy or asthma symptoms or breathing
difficulties if inhaled
May cause an allergic skin reaction
Causes damage to organs : Blood system Respiratory
system Kidney
May cause damage to organs through prolonged or
repeated exposure : Liver Visual system Kidney
Toxic to aquatic life
Precautionary statements:
Ethylenediamine Monohydrate

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Section 2. HAZARDS IDENTIFICATION
[Prevention] Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Keep container tightly closed.
Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary
measures against ignition by the static discharge and the spark.
Do not breathe dust/fume/gas/mist/vapours/spray.
Avoid release to the environment.
Do not eat, drink or smoke when using this product.
Contaminated work clothing should not be allowed out of the workplace.
Wash hands thoroughly after handling.
In case of inadequate ventilation wear respiratory protection.
Wear protective gloves and eye/face protection.
[Response] IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
if present and easy to do. Continue rinsing.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse
skin with water/shower.
If skin irritation or rash occurs: Get medical advice/attention.
Remove/Take off immediately all contaminated clothing.
Wash contaminated clothing before reuse.
Immediately call a POISON CENTER or doctor/physician.
Store in a well-ventilated place. Keep cool.
[Storage]
Store locked up.
Dispose of contents/container through a waste management company authorized by
[Disposal]
the local government.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Ethylenediamine Monohydrate
Percent: >98.0%(T)
6780-13-8
CAS Number:
Chemical Formula: C2H8N2·H2O

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. Immediately call a POISON CENTER or doctor/physician.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.Immediately call a POISON CENTER or
doctor/physician.
Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT
Ingestion:
induce vomiting.
Most important Burning sensation, Cough, Shortness of breath, Sore throat, Wheezing, Abdominal
symptoms/effects, acute pain, Collapse, Redness, Burn, Pain, Blurred Vision
and delayed:
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.
Indication of immediate Medical ovservation is indicated.
medical attantion and
special treatment needed, if
necessary:
Ethylenediamine Monohydrate

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water in large amounts, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use extra personal protective equipment (self-contained breathing apparatus). Keep
Personal precautions,
protective equipment and people away from and upwind of spill/leak. Ensure adequate ventilation. Entry to non-
emergency procedures: involved personnel should be controlled around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an
containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot
surfaces. -No smoking. Take measures to prevent the build up of electrostatic
charge. Use explosion-proof equipment. Wash hands and face thoroughly after
handling.
Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol
will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Keep container tightly closed. Store in a cool, dark and well-ventilated place.
Storage conditions:
Store under inert gas.
Store locked up.
Store away from incompatible materials such as oxidizing agents.
Air-sensitive
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Half or full facepiece respirator, self-contained breathing apparatus(SCBA), supplied
air respirator, etc. Use respirators approved under appropriate government standards
and follow local and national regulations.
Hand protection: Impervious gloves.
Eye protection: Safety goggles. A face-shield, if the situation requires.
Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Colour: Colorless - Very pale yellow
Odour: Ammoniacal
Ethylenediamine Monohydrate

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
pH: 11.9/25°C (25% H2O soln.)
Melting point/freezing point:10°C
Boiling point/range: 118°C
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: 0.96
Solubility(ies):
[Water] No data available
[Other solvents] No data available
Log Pow: -1.2

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Spark, Open flame, Static discharge
Conditions to avoid:
Incompatible materials: Oxidizing agents, Acids, Metals, Halogens
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
No data available
Crustacea:
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative <1
potential(BCF):
Mobility in soil
Log Pow: -1.2
Soil adsorption (Koc): 4766
1.8 x 10-4
Henry's Law
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: 8: Corrosive.
Subsidiary risk: 3: Flammable liquid.
Ethylenediamine Monohydrate

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Section 14. TRANSPORT INFORMATION
UN-No: 1604
Proper shipping name: Ethylenediamine
Packing group: II

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  碘化氰 、 乙二胺 在 乙醇 作用下， 生成 4,5-二氢-1H-咪唑-2-胺
  参考文献：
  名称：

  Ueber einige Guanidinderivate

  摘要：

  DOI：

  10.1002/ardp.19092470328
• 作为产物：
  描述：

  乙二胺 在 水 作用下， 生成 乙二胺
  参考文献：
  名称：

  Hofmann,A. W., Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1858, p. 343

  摘要：

  DOI：
• 作为试剂：
  描述：

  5-溴-2-硝基苯甲醛 在 乙二胺 、 iron(III) chloride hexahydrate 、 甲烷 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 80.5h， 生成 (S)-(-)-7-bromo-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxylic acid
  参考文献：
  名称：

  新型 NR2B 选择性 NMDAR 拮抗剂的鉴定和硅结合研究

  摘要：

  阿尔茨海默病（AD）是威胁人类健康的一大类疾病，对其药物和治疗方法的探索从未停止。NMDA 受体拮抗剂作为潜在治疗靶点的研究和开发也一直在进行中。我们小组基于 NR2B-NMDARs 靶标设计合成了 22 种新的四氢吡咯并[2,1– b ]喹唑啉，并评估了它们在体外对 NMDA 诱导的细胞毒性的神经保护活性，A21 表现出优异的神经保护活性。随后，四氢吡咯并 [2,1– b]的构效关系和抑制剂结合模式]喹唑啉通过分子对接、分子动力学 (MD) 模拟和结合自由能计算进一步分析。结果显示A21可以匹配NR2B-NMDARs的两个结合口袋。本项目的研究成果将为新型NR2B-NMDA受体拮抗剂的研究奠定一定的基础，也为该靶点的后续研发提供新的思路。

  DOI：

  10.1016/j.bmcl.2023.129213

文献信息

• Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones
  申请人：Janssen Pharmaceutica N.V.

  公开号：US05270464A1

  公开（公告）日：1993-12-14

  Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing anti-HIV-1 activity, compositions containing these compounds as active ingredients, and methods of treating subjects suffering from HIV-1 infection by administering these compounds. The compounds have the basic structure shown in Formula (I): ##STR1##

  新型四氢咪唑并[1,4]苯二氮杂环己烷-2-(硫)酮具有抗HIV-1活性，含有这些化合物作为活性成分的组合物，以及通过给予这些化合物治疗患有HIV-1感染的受试者的方法。这些化合物具有在式(I)中显示的基本结构：##STR1##
• Composition, synthesis and therapeutic applications of polyamines
  申请人：Murphy A Michael

  公开号：US20050085555A1

  公开（公告）日：2005-04-21

  This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

  这项发明涉及一种合成和构成开链（环）、闭环、线性分支和/或取代聚胺、聚胺衍生的酪氨酸磷酸酶抑制剂和PPAR部分激动剂/部分拮抗剂的过程，通过一系列的取代反应来优化化合物的生物利用度和生物活性。聚胺可以预防神经毒素和导致糖尿病的毒素的毒性，包括百草枯、甲基苯基吡啶自由基、洛特侬、重组蛋白酶和阿洛克瑞。这些聚胺可以用于治疗哺乳动物主体中的神经系统、心血管系统、内分泌系统获得性和遗传性线粒体DNA损伤疾病以及其他疾病，更具体地用于治疗帕金森病、阿尔茨海默病、路易氏氏病、宾斯旺格氏病、橄榄桥小脑变性、Lewy小体病、糖尿病、中风、动脉粥样硬化、心肌缺血、心肌病、肾病、缺血、青光眼、老年性耳聋、癌症、骨质疏松症、类风湿性关节炎、炎症性肠病、多发性硬化症以及作为毒素暴露的解毒剂。
• Template Synthesis of a Tetraazamacrocyclic Ligand with Two Pendant Pyridinyl Groups:  Properties of the Isomers of the Metal-Free Ligand and of Their First-Row Transition Metal Compounds
  作者：Peter Comba、Stephan M. Luther、Oliver Maas、Hans Pritzkow、Annette Vielfort

  DOI：10.1021/ic000696x

  日期：2001.5.1

  low yield (6%). Ion exchange chromatography is used for isomer separation, and the two isomers of the metal-free ligand are obtained by reduction of the copper(II) complexes and subsequent ion exchange chromatography. Crystal structure analyses of the metal-free a-pypymac ligand, of two isomeric copper(II) compounds of a-pypymac and one of s-pypymac, and of the cobalt(III) complexes of a- and s-pypymac

  [Cu（en）（2）]（2+）（en = 1,2-二氨基乙烷）与甲醛，2-吡啶基乙基乙酸乙酯和碱的一步反应生成[Cu（s-pypymac）混合物]（2+）和[Cu（a-pypymac）]（2+）（s-pypymac = syn-6,13-​​双（2-吡啶基）-1,4,8,11-四氮杂环十四烷，a-pypymac =抗6,13-​​双（2-吡啶基）-1,4,8,11-四氮杂环十四烷;顺反比约为1：9），收率低（6％）。离子交换色谱用于异构体分离，无金属配体的两个异构体是通过还原铜（II）配合物并随后进行离子交换色谱而获得的。无金属a-pypymac配体，a-pypymac的两种同分异构的铜（II）化合物和s-pypymac之一的晶体结构分析，以及a-和s-pypymac和镍的钴（III）配合物II）以及a-pypymac的锌（II）配合物，
• Power-conscious Scheduling for Real-time Embedded Systems Design
  作者：Youngsoo Shin、Kiyoung Choi、Takayasu Sakurai

  DOI：10.1155/2001/23925

  日期：2001.1.1

  Power efficient design of real-time embedded systems based on programmable processors becomes more important as system functionality is increasingly realized through software. We address a power optimization method for real-time embedded applications on a variable speed processor. The method combines off-line and on-line components. The off-line component determines the lowest possible maximum processor speed while guaranteeing deadlines of all tasks. The on-line component dynamically varies the processor speed or bring a processor into a power-down mode to exploit execution time variations and idle intervals. Experimental results show that the proposed method obtains a significant power reduction across several kinds of applications.

  基于可编程处理器的实时嵌入式系统的功耗高效设计在系统功能越来越多地通过软件实现时变得更加重要。我们提出了一种针对可变速处理器的实时嵌入式应用的功耗优化方法。该方法结合了离线和在线组件。离线组件确定了可能的最低最大处理器速度，同时保证所有任务的截止期限。在线组件动态地变化处理器速度或将处理器置于省电模式以利用执行时间变化和空闲间隙。实验结果表明，所提出的方法在多种应用程序中实现了显著的功耗降低。
• N-Thioureido and N-ureido phenylene diamines and method of preparing same
  申请人：Societe Anonyme dite: L'Oreal

  公开号：US04008272A1

  公开（公告）日：1977-02-15

  Dye compositions containing the oxidation dye: ##STR1## and the method of using it to dye live human hair.

  含氧化染料的染料组合物：##STR1##以及使用它染活的人头发的方法。