(+/-)-6'-bromo-1-methyl-3',4'-dihydro-1'H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione | 765941-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (+/-)-6'-bromo-1-methyl-3',4'-dihydro-1'H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione
• 英文别名: (+/-)-6'-bromo-3-methyl-3',4'-dihydro-1'H-spiro[imidazolidine-4, 2'-naphthalene]-2,5-dione；(+/-)-6'-Bromo-3-methyl-3',4'-dihydro-1'H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione；7-bromo-1'-methylspiro[2,4-dihydro-1H-naphthalene-3,5'-imidazolidine]-2',4'-dione
• CAS: 765941-59-1
• 化学式: C₁₃H₁₃BrN₂O₂
• 分子量: 309.162
• InChiKey: RLBROKZSVZNONG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-6'-bromo-1-methyl-3',4'-dihydro-1'H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione 、 二氧化碳 在 乙基溴化镁 、 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 0.75h， 生成 (+/-)-6'-carboxy-1-methyl-3',4'-dihydro-1'H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione
  参考文献：
  名称：

  [EN] MONOCYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS
  [FR] ANTAGONISTES DES RECEPTEURS DU CGRP D'ANILIDE SPIROHYDANTOINE MONOCYCLIQUE

  摘要：

  本发明涉及一类CGRP受体拮抗剂化合物，用于治疗或预防涉及CGRP的疾病，如头痛、偏头痛和群集性头痛。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及CGRP的疾病中使用这些化合物和组合物。

  公开号：

  WO2004083187A1
• 作为产物：
  描述：

  potassium cyanate 、 6-溴-2-四氢萘酮 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 19.33h， 生成 (+/-)-6'-bromo-1-methyl-3',4'-dihydro-1'H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione
  参考文献：
  名称：

  [EN] TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS
  [FR] ANTAGONISTE DES RECEPTEURS CGRP SPIROHYDANTOIN ANILIDE TRICYCLIQUE

  摘要：

  公开号：

  WO2006031676A3

文献信息

• [EN] ARYL SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR CGRP D'ARYL SPIROHYDANTOINE
  申请人：MERCK & CO INC

  公开号：WO2004082678A1

  公开（公告）日：2004-09-30

  The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及一种对CGRP受体具有拮抗作用的化合物，可用于治疗或预防CGRP参与的疾病，如头痛、偏头痛和集群头痛。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗CGRP参与的这类疾病中使用这些化合物和组合物。
• Monocyclic anilide spirohydantoin cgrp receptor antagonists
  申请人：Bell M. Ian

  公开号：US20060148779A1

  公开（公告）日：2006-07-06

  The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及与CGRP受体拮抗的化合物，这些化合物在治疗或预防CGRP参与的疾病，如头痛、偏头痛和群头痛方面是有用的。本发明还涉及包含这些化合物的药物组合物，以及在预防或治疗CGRP参与的这些疾病中使用这些化合物和组合物的用途。
• Aryl spirohydantoin cgrp receptor antagonists
  申请人：Bell M. Ian

  公开号：US20060189593A1

  公开（公告）日：2006-08-24

  The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及对CGRP受体的拮抗剂化合物，这些化合物可用于治疗或预防CGRP参与的疾病，如头痛、偏头痛和群集性头痛。本发明还涉及包含这些化合物的制药组合物和使用这些化合物和组合物预防或治疗CGRP参与的这些疾病。
• Benodiazepine spirohydantoin cgrp receptor antagonists
  申请人：Bell M. Ian

  公开号：US20060189600A1

  公开（公告）日：2006-08-24

  The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及一种针对CGRP受体的拮抗剂化合物，可用于治疗或预防CGRP参与的疾病，如头痛、偏头痛和群集性头痛。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗CGRP参与的这些疾病中使用这些化合物和组合物的用途。
• Bicyclic anilide spirohydantoin cgrp receptor antagonists
  申请人：Bell M. Ian

  公开号：US20060211712A1

  公开（公告）日：2006-09-21

  The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及以下公式的化合物： 该化合物是CGRP受体拮抗剂，可用于治疗或预防CGRP参与的疾病，例如头痛，偏头痛和集群性头痛。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗CGRP参与的这些疾病中使用这些化合物和组合物。