cefuzonam sodium | 82219-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: cefuzonam sodium
• 英文别名: Cosmosin；sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(thiadiazol-5-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS: 82219-81-6
• 化学式: C₁₆H₁₄N₇O₅S₄*Na
• 分子量: 535.585
• InChiKey: BCMSQWPLFBUUKW-IXLPVNPSSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.87
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  283
• 氢给体数：
  2
• 氢受体数：
  14

安全信息

• 储存条件：
  | 库房低温、通风且干燥 |

制备方法与用途

类别：有毒物质

毒性分级：低毒

急性毒性：

• 静脉注射大鼠 LD50：4222 毫克/公斤
• 静脉注射小鼠 LD50：4117 毫克/公斤

可燃性危险特性：热分解时释放有毒氮氧化物、硫氧化物和烟雾

储运特性：库房低温、通风干燥保存

灭火剂：水、二氧化碳、泡沫、干粉

反应信息

• 作为反应物：
  描述：

  cefuzonam sodium 、 碘甲醇乙酸酯 生成 acetyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(thiadiazol-5-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• AQUEOUS COMPOSITION
  申请人：Yaginuma Yoshihito

  公开号：US20100172978A1

  公开（公告）日：2010-07-08

  Disclosed is an aqueous composition containing (a) an ethyl acrylate/methyl methacrylate copolymer or a plasticized vinyl accetate polymer, (b) an ethyl cellulose, (c) a water soluble additive for pharmaceutical products, (d) titanium oxide and (c) water. The solid content mass ratio among the components (a), (b), (c) and (d), namely a:b:c:d is 100:(5-50):(1-50):(0.5-10), and the solid content concentration in the aqueous composition is 0.5-40% by mass.

  本发明涉及一种水性组合物，包含(a)乙基丙烯酸酯/甲基丙烯酸甲酯共聚物或增塑的乙烯醋酸乙烯酯聚合物，(b)乙基纤维素，(c)水溶性药品添加剂，(d)二氧化钛和(c)水。组分(a)、(b)、(c)和(d)的固体含量质量比，即a:b:c:d为100:(5-50):(1-50):(0.5-10)，水性组合物中的固体含量浓度为0.5-40%。
• CRYSTALLINE CONDITION DISLOCATING METHOD
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0665009A1

  公开（公告）日：1995-08-02

  An object of this invention is to provide a method of dislocating the crystalline condition of crystalline medicine simply, speedily and homogeneously, and, moreover, in large quantities at once. This invention is directed to a method using an extruder when crystalline medicine in a certain crystalline condition (△ is dislocated to another crystalline condition (○), i.e., when the dislocation of crystalline condition (△->○) is carried out.

  本发明的目的是提供一种简单、快速和均匀地将结晶药物的结晶状态变位的方法，而且是一次性大量变位。本发明针对的是一种使用挤压机将某种结晶状态（△）的结晶药物变位到另一种结晶状态（○）的方法，即结晶状态（△->○）变位的方法。
• Medical device and production method thereof
  申请人：UNITIKA LTD.

  公开号：EP0882461A2

  公开（公告）日：1998-12-09

  A medical device having both physiological and antimicrobial activity, comprising a base material, a cross-linked coating film formed on a surface of the base material, and each of a physiologically active substance and an antimicrobial substance bonded to the coating film. Also disclosed is a method for producing the medical device, which comprises providing a base material, forming a cross-linked coating film comprising the reaction product of a high molecular weight substance having acid anhydride groups and a compound having two or more active hydrogen atoms on a surface of the base material, and subsequently bonding each of a physiologically active substance and an antimicrobial substance to the coating film.

  一种同时具有生理活性和抗菌活性的医疗器械，包括基体材料、在基体材料表面形成的交联涂膜，以及粘合在涂膜上的生理活性物质和抗菌物质。还公开了一种生产该医疗设备的方法，该方法包括提供基体材料，在基体材料表面形成交联涂膜，该涂膜由具有酸酐基团的高分子量物质和具有两个或两个以上活性氢原子的化合物的反应产物组成，随后将生理活性物质和抗菌物质中的每一种粘合到涂膜上。
• LIPOSOMES
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP1190706A1

  公开（公告）日：2002-03-27

  Drug carriers that includes a drug, being very high in targeting capability at a diseased site such as an inflammatory site or a tumor site where pH has been decreased in acidic regions. A liposome, comprising as membrane constituents [1] a basic compound, [2] an acidic compound which is a phosphoric acid monoester derivative, or a compound having a carboxyl group or its salt, and [3] other liposome constituent.

  药物载体，包括药物，在酸性区域 pH 值降低的炎症部位或肿瘤部位等病变部位具有很强的靶向能力。一种脂质体，其膜成分包括[1]碱性化合物，[2]磷酸单酯衍生物或具有羧基的化合物或其盐类的酸性化合物，以及[3]其他脂质体成分。
• SPHERICAL CRUDE GRANULE AND METHOD FOR PRODUCTION THEREOF
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2050438A1

  公开（公告）日：2009-04-22

  The characteristic in being coated with film of spherical elementary granules is improved by adjusting a short/long diameter-ratio distribution coefficient to a specific value.

  通过将长短径比分布系数调整到特定值，可改善球形基本颗粒涂膜的特性。