{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-phenethyl-amine | 140890-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-phenethyl-amine
• 英文别名: N-[2-[bis(4-fluorophenyl)methoxy]ethyl]-2-phenylethanamine
• CAS: 140890-70-6
• 化学式: C₂₃H₂₃F₂NO
• 分子量: 367.439
• InChiKey: TVGRUCPXRHSHGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯乙醛 、 2-ethylamine maleate 在 sodium cyanoborohydride 作用下， 以 四氢呋喃 为溶剂， 生成 {2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-phenethyl-amine
  参考文献：
  名称：

  New prenylamine analogues: synthesis and Ca2+-entry blocking activity

  摘要：

  The synthesis of a series of diphenylalkylamine derivatives related to prenylamine is reported. The amphetamine group in the prenylamine structure was replaced by other moieties. In addition to substitutions in the aromatic rings, heteroatoms such as sulphur and oxygen were introduced in the chain. The calcium-entry blocking activity was assayed in binding experiments on a guinea-pig brain membrane preparation by displacing [H-3]-nitrendipine.

  DOI：

  10.1016/0223-5234(92)90136-o

文献信息

• Benzhydryl derivatives having calmodulin inhibitor properties
  申请人：Akzo Nobel N.V.

  公开号：EP0467435A2

  公开（公告）日：1992-01-22

  The invention relates to a benzhydryl derivative having the formula wherein each of the groups Ri, R2, and R3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF3, and at least one of the groups Ri, R2, and R3 is halogen or CF3; R4 represents hydrogen or methyl; n is 2, 3, or 4; m is 1, 2, or 3; and X represents O or S; or its pharmaceutically acceptable salts. The benzhydryl derivative of the invention can be used to treat patients who are suffering from diseases which are influenced by calmodulin.

  本发明涉及一种具有以下式子的苯甲酰衍生物 其中每个基团 Ri、R2 和 R3 代表一至四个取代基，这些取代基独立地选自氢、低级烷基、卤素和 CF3 组成的组，且至少一个基团 Ri、R2 和 R3 是卤素或 CF3； R4 代表氢或甲基； n 是 2、3 或 4； m 是 1、2 或 3；以及 X 代表 O 或 S； 或其药学上可接受的盐类。 本发明的苄基衍生物可用于治疗受钙调素影响的疾病患者。
• US5171752A
  申请人：——

  公开号：US5171752A

  公开（公告）日：1992-12-15
• New prenylamine analogues: synthesis and Ca2+-entry blocking activity
  作者：PM Caldirola、H van der Goot、H Timmerman

  DOI：10.1016/0223-5234(92)90136-o

  日期：1992.9

  The synthesis of a series of diphenylalkylamine derivatives related to prenylamine is reported. The amphetamine group in the prenylamine structure was replaced by other moieties. In addition to substitutions in the aromatic rings, heteroatoms such as sulphur and oxygen were introduced in the chain. The calcium-entry blocking activity was assayed in binding experiments on a guinea-pig brain membrane preparation by displacing [H-3]-nitrendipine.