hydron;2-methyl-N-(2-methylphenyl)-2-(propylamino)propanamide;chloride | 6205-09-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: hydron;2-methyl-N-(2-methylphenyl)-2-(propylamino)propanamide;chloride
• CAS: 6205-09-0
• 化学式: C14H23ClN2O
• 分子量: 270.8
• InChiKey: DTPYLPGGXSBZSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.13
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.1
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• METHOD FOR IMPROVING THE AQUEOUS SOLUBILITY OF POORLY-SOLUBLE SUBSTANCES
  申请人：KABUSHIKI KAISHA SANGI

  公开号：EP2484383A1

  公开（公告）日：2012-08-08

  Provided is a method for increasing the solubility of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, without using large amounts of additives. This is a method for improving aqueous solubility, which comprises coating the surface of the particle of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, with microparticles of a calcium compound such as calcium phosphate or calcium carbonate.

  本发明提供了一种在不使用大量添加剂的情况下提高用于医药产品、兽医药品、准药品、化妆品、食品、农药等的难溶性物质溶解度的方法。这是一种提高水溶性的方法，它包括在用于医药产品、兽医药品、准药品、化妆品、食品、农药等的难溶性物质的颗粒表面涂上钙化合物微粒，如磷酸钙或碳酸钙。
• METHOD FOR IMPROVING WATER SOLUBILITY OF SLIGHTLY SOLUBLE SUBSTANCE
  申请人：Kabushiki Kaisha Sangi

  公开号：EP2821084A1

  公开（公告）日：2015-01-07

  It is an object of the present invention to provide a method for improving the solubility of a poorly-soluble substance, which is capable of increasing the solubility of substantially all poorly-soluble substances. This is a method comprising coating the surface of a poorly-soluble substance particle with microparticles of a calcium compound such as calcium phosphate or calcium carbonate, and at least one selected from a pH adjuster and a surfactant, by applying mechanical energy thereto.

  本发明的目的是提供一种提高难溶物质溶解度的方法，这种方法能够提高基本上所有难溶物质的溶解度。该方法包括通过机械能在难溶物质颗粒表面涂上钙化合物微粒，如磷酸钙或碳酸钙，以及至少一种选自 pH 调整剂和表面活性剂的微粒。
• AGGREGATION INHIBITORY AGENT AND MEDICAL COMPOSITION AND MEDICAL DEVICE INCLUDING SAME
  申请人：Nipro Corporation

  公开号：EP4079325A1

  公开（公告）日：2022-10-26

  An anti-aggregation agent of the present invention contains, as an anti-aggregation ingredient, at least one selected from the group consisting of polyoxyethylene cetyl ether, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene polyoxypropylene glycols having an average molecular weight of 3000 to 13000. According to the present invention, in a container whose inner wall is treated with silicone oil, aggregation of a poorly water-soluble drug caused by the silicone oil can be prevented.

  本发明的抗聚集剂含有至少一种从聚氧乙烯十六烷基醚、聚氧乙烯山梨糖醇脂肪酸酯和聚氧乙烯聚氧丙二醇组成的组中选出的抗聚集成分，其平均分子量为 3000 至 13000。根据本发明，在内壁经过硅油处理的容器中，可以防止由硅油引起的水溶性差的药物聚集。
• HYDROPHILIC POLYMER-SILICATE MINERAL COMPOSITE AND ITS USE
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0450094B1

  公开（公告）日：1996-10-02
• Method for Improving the Aqueous Solubility of Poorly-Soluble Substances
  申请人：Sakuma Shuji

  公开号：US20120264608A1

  公开（公告）日：2012-10-18

  Provided is a method for increasing the solubility of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, without using large amounts of additives. This is a method for improving aqueous solubility, which comprises coating the surface of the particle of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, with microparticles of a calcium compound such as calcium phosphate or calcium carbonate.