| 1362047-92-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• CAS: 1362047-92-4
• 化学式: C₁₄H₁₅NO₃
• 分子量: 245.278
• InChiKey: FHJXIEHZXRWDOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.89
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  异丁酰醋酸甲酯 在 吡啶 、 盐酸羟胺 作用下， 以 水 为溶剂， 反应 0.75h， 生成
  参考文献：
  名称：

  Efficient One-Pot Synthesis of β-Unsaturated Isoxazol-5-ones and Pyrazol-5-ones Under Ultrasonic Irradiation

  摘要：

  4-Arylmethylidene-3-isopropylisoxazol-5-ones and 4-arylmethylidene-1-phenyl-3-isopropylpyrazol-5-ones have been prepared from the reactions of hydroxylamine and phenylhydrazine with methyl 4-methyl-3-oxovalerate and aromatic aldehydes in an aqueous medium at room temperature in the presence of pyridine under ultrasonic irradiation. The simple and facile method produced products in good yields.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2010.535949

文献信息

• Efficient One-Pot Synthesis of <font>β</font>-Unsaturated Isoxazol-5-ones and Pyrazol-5-ones Under Ultrasonic Irradiation
  作者：Keyume Ablajan、Hainimu Xiamuxi

  DOI：10.1080/00397911.2010.535949

  日期：2012.4.15

  4-Arylmethylidene-3-isopropylisoxazol-5-ones and 4-arylmethylidene-1-phenyl-3-isopropylpyrazol-5-ones have been prepared from the reactions of hydroxylamine and phenylhydrazine with methyl 4-methyl-3-oxovalerate and aromatic aldehydes in an aqueous medium at room temperature in the presence of pyridine under ultrasonic irradiation. The simple and facile method produced products in good yields.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.