1-(2-Deoxy-β-D-erythro-pentofuranosyluronsaeure)-cytosin | 4603-72-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(2-Deoxy-β-D-erythro-pentofuranosyluronsaeure)-cytosin
• 英文别名: 1-(4-amino-2-oxo-2H-pyrimidin-1-yl)-β-D-erythro-1,2-dideoxy-pentofuranuronic acid；5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-carboxylic acid；5-Carboxyl-2'-deoxycytidine；(2S,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolane-2-carboxylic acid
• CAS: 4603-72-9
• 化学式: C₉H₁₁N₃O₅
• 分子量: 241.203
• InChiKey: IXVVOPMSSSJGMB-JHYUDYDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-benzoyloxy-tetrahydro-furan-2-carboxylic acid 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以90%的产率得到1-(2-Deoxy-β-D-erythro-pentofuranosyluronsaeure)-cytosin
  参考文献：
  名称：

  [EN] INHIBITORS OF RNA DEPENDENT RNA POLYMERASE AND USES THEREOF
  [FR] INHIBITEURS D'ARN DEPENDANT D'ARN POLYMERASE ET LEURS UTILISATIONS

  摘要：

  本发明提供了新型病毒DNA聚合酶化合物。本发明还提供了包括这些化合物的药物组合物，使用这些化合物治疗与病毒DNA聚合酶活性相关的疾病的方法，以及用于制备这些化合物的过程和中间体。

  公开号：

  WO2004011479A1

文献信息

• METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS
  申请人：Srivastava Rakesh

  公开号：US20110172234A1

  公开（公告）日：2011-07-14

  This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies.
• [EN] INHIBITORS OF RNA DEPENDENT RNA POLYMERASE AND USES THEREOF<br/>[FR] INHIBITEURS D'ARN DEPENDANT D'ARN POLYMERASE ET LEURS UTILISATIONS
  申请人：MICROLOGIX BIOTECH INC

  公开号：WO2004011479A1

  公开（公告）日：2004-02-05

  The invention herein provides novel viral DNA polymerase compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with viral DNA polymerase activity, and processes and intermediates useful for preparing such compounds.

  本发明提供了新型病毒DNA聚合酶化合物。本发明还提供了包括这些化合物的药物组合物，使用这些化合物治疗与病毒DNA聚合酶活性相关的疾病的方法，以及用于制备这些化合物的过程和中间体。