1-Isopropyl-3,5-bis(4-methoxybenzylidene)-4-piperidinone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Isopropyl-3,5-bis(4-methoxybenzylidene)-4-piperidinone
• 英文别名: (3E,5E)-3,5-bis[(4-methoxyphenyl)methylidene]-1-propan-2-ylpiperidin-4-one
• 化学式: C₂₄H₂₇NO₃
• 分子量: 377.5
• InChiKey: KBLAWEKNXODCJI-KVVJQUGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 3,5-DIARYLIDENYL-N-SUBSTITUTED-PIPERID-4-ONE-DERIVED INHIBITORS OF STAT3 PATHWAY ACTIVITY AND USES THEREOF
  申请人：Kiakos Konstantinos

  公开号：US20200399220A1

  公开（公告）日：2020-12-24

  3,5-Diarylidenyl-N-substituted-piperid-4-one analogs, and pharmaceutically acceptable derivatives thereof, are useful in the treatment or prevention of disorders including cancer, autoimmune disorders, inflammatory disorders, and fibrotic disorders. The compounds are included in pharmaceutical compositions, and are useful for treating disorders, such as cancer associated with aberrant Stat3 pathway activity. The compositions further include another therapeutic agent, such as an anticancer drug. Such compounds or compositions thereof are used to treat resistant and/or metastatic cancers. Methods also inhibit Stat3 pathway activity in a cell. Other methods are useful for making the pharmaceutical compounds. Synthetic methods are also useful for making the compounds. The compounds and compositions are useful as a fluorescent probe.