N,N'-bis(2-hydroxyphenyl)ethylenediamine-N,N'-diacetic acid | 10328-28-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis(2-hydroxyphenyl)ethylenediamine-N,N'-diacetic acid
• 英文别名: N,N'-Aethylen-bis-；N,N'-bis(2-hydroxyphenyl)ethylenediiminodiacetic acid；ethylenebis-(2-hydroxy-phenylglycine)；2,2'-(Ethane-1,2-diylbis((2-hydroxyphenyl)azanediyl))diacetic acid；2-[N-[2-[N-(carboxymethyl)-2-hydroxyanilino]ethyl]-2-hydroxyanilino]acetic acid
• CAS: 10328-28-6
• 化学式: C₁₈H₂₀N₂O₆
• 分子量: 360.367
• InChiKey: YFMDCHTYRWCFRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  595.5±50.0 °C(Predicted)
• 密度：
  1.468±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N,N'-bis(2-hydroxyphenyl)ethylenediamine-N,N'-diacetic acid 、 copper(II) nitrate 以 水 、 甘油 为溶剂， 生成
  参考文献：
  名称：

  Coordination chemistry of N,N′-bis(2-hydroxyphenyl)ethylenediamine-N,N′-diacetic acid and some related ligands

  摘要：

  DOI：

  10.1016/s0277-5387(00)86578-x

文献信息

• [EN] SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS<br/>[FR] MOLÉCULES À AUTO-ASSEMBLAGE QUI S'ACCUMULENT DANS DES MICROENVIRONNEMENTS TUMORAUX ACIDES
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2016022987A1

  公开（公告）日：2016-02-11

  Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles while in blood serum into cylindrical nanofibers in the acidic extracellular environment of tumors, which can be used to achieve a higher relative concentration of imaging, drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.

  披露的是含有多种生物相容性自组装分子的组合物，这些分子在血清中从孤立分子或球形胶束转变为在肿瘤酸性细胞外环境中的柱状纳米纤维，可用于在肿瘤部位实现相对较高浓度的成像、药物输送或放射治疗剂，相比非肿瘤组织。这种转变是快速且可逆的，表明系统处于热力学平衡状态。
• SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS
  申请人：The Ohio State University

  公开号：US20140363378A1

  公开（公告）日：2014-12-11

  Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles in the circulation into cylindrical nanofibers in the acidic extracellular environment of tumors which can be used to achieve a higher relative concentration of imaging, drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.

  揭示了包含多种生物相容性自组装分子的组合物，这些分子在循环中从孤立分子或球形胶束转变为肿瘤酸性细胞外环境中的圆柱形纳米纤维，可用于在肿瘤部位实现成像、药物传递或放射治疗剂的相对浓度高于非肿瘤组织。这种转变是快速且可逆的，表明系统处于热力学平衡状态。
• Gastrin releasing peptide compounds
  申请人：——

  公开号：US20040136906A1

  公开（公告）日：2004-07-15

  New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.

  新的和改进的化合物，可用于放射性诊断成像或放射治疗，具有公式M-N—O—P-G，其中M是金属螯合剂（以与金属放射性核素或未结合的形式），N—O—P是连接物，G是GRP受体靶向肽。本发明还提供了利用这些化合物对患者进行成像和/或放射治疗的方法。还提供了从该化合物制备诊断成像试剂的方法。还提供了制备放射治疗试剂的方法。
• Multivalent constructs for therapeutic and diagnostic applications
  申请人：Arbogast Christophe

  公开号：US20050027105A9

  公开（公告）日：2005-02-03

  The invention provides compositions and methods for therapeutic and diagnostic applications.

  本发明提供了治疗和诊断应用的组合物和方法。
• KDR and VEGF/KDR binding peptides
  申请人：Sato K. Aaron

  公开号：US20050250700A1

  公开（公告）日：2005-11-10

  The present invention provides, inter alia, peptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K D <1 μM), and dimer and multimeric constructs comprising these polypeptides.

  本发明提供了包含至少一个与KDR或VEGF/KDR复合物结合基团的肽、肽二聚体和多聚复合物，这些复合物在治疗、检测、分离或定位血管生成具有各种用途。特别披露了能够与KDR或VEGF/KDR复合物高亲和力结合的合成、分离多肽（例如具有KD<1μM的多肽）以及包含这些多肽的二聚体和多聚体构造。