N^ε-tert-Butoxycarbonyl-L-lysyl-L-proline methylester | 69323-12-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^ε-tert-Butoxycarbonyl-L-lysyl-L-proline methylester
• 英文别名: H-Lys(Boc)-Pro-OMe；methyl (2S)-1-[(2S)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]pyrrolidine-2-carboxylate
• CAS: 69323-12-2
• 化学式: C₁₇H₃₁N₃O₅
• 分子量: 357.45
• InChiKey: IOSZLIZTXMEUEY-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Ethyl 2-bromo-9-phthalimidononanoate 、 N^ε-tert-Butoxycarbonyl-L-lysyl-L-proline methylester 生成 N-<8-Amino-1-carboxyoctyl>-N^ε-carbobenzoxy-L-lysyl-L-proline
  参考文献：
  名称：

  Saito; Matsui; Watanabe, Arzneimittel-Forschung/Drug Research, 1990, vol. 40, # 10, p. 1078 - 1081

  摘要：

  DOI：

文献信息

• Nucleic acids encoding engineered imine reductases
  申请人：CODEXIS, INC.

  公开号：US10308966B2

  公开（公告）日：2019-06-04

  The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

  本公开提供了具有亚胺还原酶活性的工程多肽、编码工程亚胺还原酶的多核苷酸、能够表达工程亚胺还原酶的宿主细胞，以及使用这些工程多肽与一系列酮和胺底物化合物制备仲胺和叔胺产物化合物的方法。
• Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
  申请人：Codexis, Inc.

  公开号：US10370648B2

  公开（公告）日：2019-08-06

  The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

  本申请提供了具有亚胺还原酶活性的工程多肽、编码工程亚胺还原酶的多核苷酸、能够表达工程亚胺还原酶的宿主细胞，以及使用这些工程多肽与一系列酮和胺底物化合物制备仲胺和叔胺产物化合物的方法。
• ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
  申请人：Codexis, Inc.

  公开号：EP2847214B1

  公开（公告）日：2017-12-27
• Engineered imine reductases and methods for the reductive animation of ketone and amine compounds.
  申请人：Haibin CHEN

  公开号：US20130302859A1

  公开（公告）日：2013-11-14

  The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
• US9193957B2
  申请人：——

  公开号：US9193957B2

  公开（公告）日：2015-11-24