neo-pentyl morpholine-4-carboxylate | 1609376-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: neo-pentyl morpholine-4-carboxylate
• 英文别名: 2,2-Dimethylpropyl morpholine-4-carboxylate
• CAS: 1609376-17-1
• 化学式: C₁₀H₁₉NO₃
• 分子量: 201.266
• InChiKey: LABUBGRLOHJREI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  neo-pentyl 1H-imidazole-1-carboxylate 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 48.0h， 生成 neo-pentyl morpholine-4-carboxylate
  参考文献：
  名称：

  Method for the synthesis of N-alkyl-O-alkyl carbamates

  摘要：

  合成N-烷基，O-烷基氨基甲酸酯的简单三步方法。

  DOI：

  10.1039/c4ra00373j

文献信息

• Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same
  申请人：CHO Dong-Gyu

  公开号：US20100004440A1

  公开（公告）日：2010-01-07

  The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

  本发明涉及一种无环核苷酸膦酸酯衍生物，其可用作抗病毒剂（特别是针对乙型肝炎病毒），药学上可接受的盐，立体异构体以及其制备方法。
• Epoxyketone compounds for enzyme inhibition
  申请人：CENTRAX INTERNATIONAL, INC.

  公开号：US10640533B2

  公开（公告）日：2020-05-05

  The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein have improved proteasome potency and selectivity, and increased aqueous solubility, and are useful in treating various conditions or diseases associated with proteasomes.

  本公开涉及可用作蛋白酶体抑制剂的新型化合物及其药物组合物。本文所提供的化合物具有更好的蛋白酶体效力和选择性，以及更高的水溶性，可用于治疗与蛋白酶体相关的各种病症或疾病。
• EPOXYKETONE COMPOUNDS FOR ENZYME INHIBITION
  申请人：CENTRAX INTERNATIONAL, INC.

  公开号：US20170158734A1

  公开（公告）日：2017-06-08

  The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein have improved proteasome potency and selectivity, and increased aqueous solubility, and are useful in treating various conditions or diseases associated with proteasomes.
• 10-(DI(PHENYL)METHYL)-4-HYDROXY-8,9,9A,10-TETRAHYDRO-7H-PYRROLO[1 ',2':4,5]PYRAZINO[1,2-B]PYRIDAZINE-3,5-DIONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE ORTHOMYXOVIRUS REPLICATION FOR TREATING INFLUENZA
  申请人：Novartis AG

  公开号：US20200407366A1

  公开（公告）日：2020-12-31

  The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
• Compounds for Treating Neurodegenerative Diseases and Cancers
  申请人：Hongyi & Associates LLC

  公开号：US20220048893A1

  公开（公告）日：2022-02-17

  The present invention relates to novel substituted aromatic-aliphatic amines capable of penetrating blood brain barrier and mediating pathogenic process in neurodegenerative diseases.