3-[5-(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methyl-benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-[5-(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methyl-benzamide
• 英文别名: 3-[5-(5-chloro-1-methyl-6-oxopyridin-3-yl)-6-(4-chloro-2-methylphenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide
• 化学式: C₃₁H₃₀Cl₂N₄O₄
• 分子量: 593.51
• InChiKey: LXTGXLSPSBMXFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PYRROLOPYRROLIDINONE COMPOUNDS
  申请人：Novartis AG

  公开号：EP2855483A1

  公开（公告）日：2015-04-08
• US9365576B2
  申请人：——

  公开号：US9365576B2

  公开（公告）日：2016-06-14
• [EN] PYRROLOPYRROLIDINONE COMPOUNDS<br/>[FR] COMPOSÉS PYRROLOPYRROLIDINONES
  申请人：NOVARTIS AG

  公开号：WO2013175417A1

  公开（公告）日：2013-11-28

  The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.