(2R,5R,6R)-2-(hydroxymethyl)-6-octoxyoxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,5R,6R)-2-(hydroxymethyl)-6-octoxyoxane-3,4,5-triol
• 化学式: C₁₄H₂₈O₆
• 分子量: 292.37
• InChiKey: HEGSGKPQLMEBJL-MGBPRESASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHODS FOR REDUCING LEVELS OF PROTEIN-CONTAMINANT COMPLEXES AND AGGREGATES IN PROTEIN PREPARATIONS BY TREATMENT WITH ELECTROPOSITIVE ORGANIC ADDITIVES
  申请人：Agency for Science, Technology and Research

  公开号：EP2855502A1

  公开（公告）日：2015-04-08
• [EN] METHODS FOR REDUCING LEVELS OF PROTEIN-CONTAMINANT COMPLEXES AND AGGREGATES IN PROTEIN PREPARATIONS BY TREATMENT WITH ELECTROPOSITIVE ORGANIC ADDITIVES<br/>[FR] PROCÉDÉS DE RÉDUCTION DES NIVEAUX DE COMPLEXES PROTÉINE-CONTAMINANT ET D'AGRÉGATS DANS DES PRÉPARATIONS PROTÉIQUES PAR TRAITEMENT AVEC DES ADDITIFS ORGANIQUES ÉLECTROPOSITIFS
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2013180650A1

  公开（公告）日：2013-12-05

  Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.