(1-acetylnaphthalen-2-yl) (2S)-2-aminopropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1-acetylnaphthalen-2-yl) (2S)-2-aminopropanoate
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.28
• InChiKey: ZPXFODNOZQSBBE-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Proteolically resistant cyclotides with angiotensin 1-7 like activity
  申请人：University of Southern California

  公开号：US10988522B2

  公开（公告）日：2021-04-27

  Described herein is a novel cyclotide able to activate the unique receptor of angiotensin-(1-7) (AT1-7), the MAS1 receptor. This cyclotide may be used in the treatment of cancer and myocardial infarction.

  本文描述的是一种新型环肽，能够激活血管紧张素-(1-7)（AT1-7）的独特受体--MAS1受体。这种环肽可用于治疗癌症和心肌梗塞。
• PROTEOLICALLY RESISTANT CYCLOTIDES WITH ANGIOTENSIN 1-7 LIKE ACTIVITY
  申请人：Camarero Palao Julio A.

  公开号：US20170218040A1

  公开（公告）日：2017-08-03

  Described herein is a novel cyclotide able to activate the unique receptor of angiotensin-(1-7) (AT1-7), the MAS1 receptor. This cyclotide may be used in the treatment of cancer and myocardial infarction.
• [EN] CYCLOTIDE-BASED CXCR4 ANTAGONISTS WITH ANTI-HIV ACTIVITY<br/>[FR] ANTAGONISTES DE CXCR4 BASÉS SUR UN CYCLOTIDE ET PRÉSENTANT UNE ACTIVITÉ ANTI-VIH
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2014046732A1

  公开（公告）日：2014-03-27

  Disclosed is an isolated peptide comprising a CXCR4 antagonist peptide grafted to a cyclotide. Also described are compositions and methods for treating cancer and HIV infections using the isolated peptides.
• [EN] PREPARATION OF CYCLOTIDES<br/>[FR] PRÉPARATION DE CYCLOTIDES
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2014046731A1

  公开（公告）日：2014-03-27

  Provided are compositions and methods for preparing a cyclotide, in particular a cyclotide with one or more unnatural amino acids. Also provided is a polypeptide comprising a linear cyclotide fused to a C-terminal fragment and an N-terminal fragment of a split intein, at the N-terminus and C-terminus of the cyclotide, respectively. Methods of establishing screening libraries of cyclotides and use of the library for identifying pharmaceutical, therapeutic or cosmetic agents are also provided.