[(2R,5R)-7-[(4-methoxyphenyl)methyl]spiro[7,8-diazabicyclo[4.2.0]oct-1(6)-ene-5,2'-oxirane]-2-yl] N-propan-2-ylcarbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [(2R,5R)-7-[(4-methoxyphenyl)methyl]spiro[7,8-diazabicyclo[4.2.0]oct-1(6)-ene-5,2'-oxirane]-2-yl] N-propan-2-ylcarbamate
• 化学式: C₁₉H₂₅N₃O₄
• 分子量: 359.4
• InChiKey: JMBQEMHYDRFYLJ-BEFAXECRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  80.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• New spiroepoxide tetrahydrobenzo-triazoles and -imidazoles and their use as MetAP-II inhibitors
  申请人：Deutsches Krebsforschungszentrum

  公开号：EP2711367A1

  公开（公告）日：2014-03-26

  The present invention relates to new spiroepoxide tetrahydrobenzo-triazole and - imidazole compounds, a method for their production and their use as MetAP-II inhibitors, which are particularly useful as inhibitors of angiogenesis. The compounds are characterized by formula (I) X=CorN R1 = OC(O)R2 where R2 is alkyl, cycloalkyl, aryl, heteroaryl, or cinnamyl or R1 = OC(O)NHR3 where R3 is alkyl, cycloalkyl, aryl, or heteroaryl or R1 = NHC(O)OR4 where R4 is alkyl or R1 = OH, NH2 R5 = alkyl, cycloalkyl, CH2R6 where R6 is aryl or heteroaryl

  本发明涉及新的螺环氧四氢苯并三唑和咪唑化合物，它们的制备方法以及它们作为MetAP-II抑制剂的用途，特别是作为抑制血管生成的抑制剂。这些化合物的特征是公式（I）X=CorNR1=OC（O）R2，其中R2是烷基，环烷基，芳基，杂芳基或肉桂基，或R1=OC（O）NHR3，其中R3是烷基，环烷基，芳基或杂芳基，或R1=NHC（O）OR4，其中R4是烷基，或R1=OH，NH2，R5=烷基，环烷基，CH2，R6是芳基或杂芳基。
• [EN] NEW SPIROEPOXIDE TETRAHYDROBENZOTRIAZOLES AND THEIR USE AS METAP-II INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS TÉTRAHYDROBENZOTRIAZOLE SPIROÉPOXYDES ET LEUR UTILISATION COMME INHIBITEURS DE METAP-II
  申请人：DEUTSCHES KREBSFORSCH

  公开号：WO2014044399A1

  公开（公告）日：2014-03-27

  The present invention relates to new spiroepoxide tetrahydrobenzotriazole compounds, a method for their production and their use as MetAP-II inhibitors, which are particularly useful as inhibitors of angiogenesis. The compounds are characterized by formula (I) R1 = OC(O)R2 where R2 is alkyl, cycloalkyl, aryl, heteroaryl, or cinnamyl or R1 = OC(0)NHR3 where R3 is alkyl, cycloalkyl, aryl, or heteroaryl or R1 = NHC(0)OR4 where R4 is alkyl or R1 = OH, NH2 R5 = alkyl, cycloalkyl, CH2R6 where R6 is aryl or heteroaryl