Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate
• 英文别名: 9-bicyclo[6.1.0]non-4-ynylmethyl N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate
• 化学式: C₁₇H₂₈N₂O₄
• 分子量: 324.4
• InChiKey: YZGOWXGENSKDSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• IMPROVED CLOT RETRIEVAL DEVICES AND THERAPEUTIC USE THEREOF
  申请人：Balt Extrusion

  公开号：EP4023269A1

  公开（公告）日：2022-07-06

  The present invention relates to improved clot retrieval devices, wherein at least the part of the device intended to be in contact with a clot is coated with at least one chromatin binding agent selected from the group consisting of digoxigenin, a digoxigenin derivative, distamycin and a distamycin derivative. The present invention also relates to a method of producing said improved clot retrieval device. The present invention also relates to a method of prevention and/or treatment of stroke in a subject, comprising removing at least one clot using the clot retrieval device coated with said least one chromatin binding agent.

  本发明涉及改进的血凝块取出装置，其中该装置至少与血凝块接触的部分涂有至少一种染色质结合剂，该染色质结合剂选自地高辛、地高辛衍生物、地霉素和地霉素衍生物组成的组。本发明还涉及一种生产所述改进型血块回收装置的方法。本发明还涉及一种预防和/或治疗受试者中风的方法，包括使用涂有所述至少一种染色质结合剂的血块取出装置取出至少一个血块。
• Cell lines
  申请人：MEDIMMUNE LIMITED

  公开号：US10253345B2

  公开（公告）日：2019-04-09

  There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.

  除其他外，还提供了一种稳定真核细胞系的方法，该细胞系表达 PylRS 和 tRNAPyl，适于加入编码含有一个或多个由无意义密码子编码的非天然氨基酸的目标蛋白质的基因，该方法包括在减少或消除 tRNAPyl 表达对细胞活力和/或细胞生长的不利影响的条件下培养所述细胞系。
• US20150259721A1
  申请人：——

  公开号：US20150259721A1

  公开（公告）日：2015-09-17
• CELL LINES
  申请人：MEDIMMUNE LIMITED

  公开号：US20170306381A1

  公开（公告）日：2017-10-26

  There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
• US9732367B2
  申请人：——

  公开号：US9732367B2

  公开（公告）日：2017-08-15