3-(2-Methoxy-2-oxoethyl)sulfanyl-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(2-Methoxy-2-oxoethyl)sulfanyl-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
• 英文别名: 3-(2-methoxy-2-oxoethyl)sulfanyl-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
• 化学式: C₁₃H₂₃NO₆S
• 分子量: 321.39
• InChiKey: IWIDGNPOWISMKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• IAP ANTAGONISTS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160376307A1

  公开（公告）日：2016-12-29

  There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

  披露了调节凋亡抑制因子（IAPs）活性的化合物，包含该化合物的药物组合物以及利用本发明的化合物治疗增生性疾病和凋亡失调疾病，如癌症的方法。
• 1,2,3,4-Tetrahydroisoquinoline-pyrrolidine derivatives as antagonists of apoptosis (IAPs) for the treatment of cancer.
  申请人：Bristol-Myers Squibb Company

  公开号：EP2861581B1

  公开（公告）日：2017-02-01
• US9637518B2
  申请人：——

  公开号：US9637518B2

  公开（公告）日：2017-05-02
• US9783573B2
  申请人：——

  公开号：US9783573B2

  公开（公告）日：2017-10-10
• [EN] IAP ANTAGONISTS<br/>[FR] ANTAGONISTES D'IAP
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014047024A1

  公开（公告）日：2014-03-27

  There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (lAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention. (Formula (I))