4-Tert-butylheptanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Tert-butylheptanoic acid
• 英文别名: 4-tert-butylheptanoic acid
• 化学式: C₁₁H₂₂O₂
• 分子量: 186.29
• InChiKey: MKEQCFNCBQVNKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：SANOFI

  公开号：US20140088158A1

  公开（公告）日：2014-03-27

  The present invention relates to compounds of the formula I, wherein A, Y, Z, R 20 to R 22 and R 50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA 1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

  本发明涉及公式I的化合物，其中A、Y、Z、R20至R22和R50具有所述权利要求中所示的含义，它们是有价值的药物活性化合物。具体来说，它们是内皮分化基因受体2（Edg-2，EDG2）的抑制剂，该受体被溶血磷脂酸（LPA）激活，也称为LPA1受体，并且对于治疗动脉粥样硬化、心肌梗死和心力衰竭等疾病有用。本发明还涉及公式I化合物的制备方法、它们的用途以及包含它们的药物组合物。
• US9018383B2
  申请人：——

  公开号：US9018383B2

  公开（公告）日：2015-04-28