O-[({[(2R)-1-(2,6-diamino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(hydroxy)phosphoryl]-N-octyl-L-tyrosinamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O-[({[(2R)-1-(2,6-diamino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(hydroxy)phosphoryl]-N-octyl-L-tyrosinamide
• 英文别名: [4-[(2S)-2-amino-3-(octylamino)-3-oxopropyl]phenoxy]-[[(2R)-1-(2,6-diaminopurin-9-yl)propan-2-yl]oxymethyl]phosphinic acid
• 化学式: C₂₆H₄₁N₈O₅P
• 分子量: 576.636
• InChiKey: KCZXTMQMYLNZOU-NQIIRXRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  40
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  207
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• METHOD TO IMPROVE ANTIVIRAL ACTIVITY OF NUCLEOTIDE ANALOGUE DRUGS
  申请人：McKenna Charles E.

  公开号：US20140100186A1

  公开（公告）日：2014-04-10

  A method of modifying a nucleotide or a nucleotide analogue to increase its overall effectiveness in treating an antiviral disease is provided. In some cases, a compound comprising a base, sugar, phosphonate moiety, and amino acid residue is provided, where the base-sugar may be a nucleoside, and the amino acid residue may be a tyrosine residue. In certain cases, the tyrosine residue contains a long chain alkyl group on the carboxamide group of the residue. Methods of inhibiting viral replication and methods of treating a viral infection are also provided.
• US9550803B2
  申请人：——

  公开号：US9550803B2

  公开（公告）日：2017-01-24