1,1-Dioxo-1,2-benzothiazol-3-one;phosphono dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 1,1-Dioxo-1,2-benzothiazol-3-one;phosphono dihydrogen phosphate
• 英文别名: 1,1-dioxo-1,2-benzothiazol-3-one;phosphono dihydrogen phosphate
• 化学式: C7H9NO10P2S
• 分子量: 361.16
• InChiKey: HBBIMFQPLXCVAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.69
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  196
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• METHOD FOR PRODUCING POLYSACCHARIDE
  申请人：Sanyo Chemical Industries, Ltd.

  公开号：EP2719767A1

  公开（公告）日：2014-04-16

  The present invention aims to provide a method for producing a polysaccharide with high efficiency using a polysaccharide synthase. The present invention provides a method for producing a polysaccharide, including allowing polysaccharide synthase (B) to act on ribonucleoside diphosphate-monosaccharide (A) shown below to produce a polysaccharide, wherein in 10 to 100% of the duration in which (B) acts on (A), the concentration of ribonucleoside diphosphate in a reaction solution is lower than 100 times an inhibitory concentration IC50 described below against polysaccharide synthase (B). Inhibitory concentration IC50: a concentration of ribonucleoside diphosphate at which an enzyme activity of polysaccharide synthase (B) is reduced by half while under a condition where (B) has a concentration at which (B) acts on ribonucleoside diphosphate-monosaccharide (A), wherein ribonucleoside diphosphate-monosaccharide (A) is used as a substrate and ribonucleoside diphosphate is used as an inhibitor. Ribonucleoside diphosphate-monosaccharide (A): a sugar nucleotide in which a proton of at least one hydroxyl group of at least one monosaccharide (a) selected from the group consisting of triose (a-1), tetrose (a-2), pentose (a-3), hexose (a-4), heptose (a-5), and monosaccharide (a-6) described below is substituted with a functional group represented by any one of chemical formulae (1) to (5) below. Monosaccharide (a-6) : a monosaccharide selected from the group consisting of (a-1), (a-2), (a-3), (a-4), and (a-5), in which at least one member selected from the group consisting of a proton, a hydroxyl group, and a hydroxymethyl group of the monosaccharide is substituted with substituent (E) described below. Substituent (E) is at least one substituent selected from the group consisting of carboxyl, amino, N-acetylamino, sulfate, methylester, N-glycolyl, methyl, 1,2,3-trihydroxypropyl, phosphate, and 2-carboxy-2-hydroxyethyl groups.

  本发明旨在提供一种利用多糖合成酶高效生产多糖的方法。本发明提供了一种生产多糖的方法，包括让多糖合成酶（B）作用于下图所示的核糖核苷二磷酸-单糖（A）以生产多糖，其中在（B）作用于（A）的10至100%的持续时间内，反应溶液中核糖核苷二磷酸的浓度低于下述对多糖合成酶（B）的抑制浓度IC50的100倍。 抑制浓度 IC50：在(B)对核糖核苷二磷酸单糖(A)起作用的浓度条件下，多糖合成酶(B)的酶活性降低一半的核糖核苷二磷酸浓度，其中核糖核苷二磷酸单糖(A)用作底物，核糖核苷二磷酸用作抑制剂。 核糖核苷二磷酸-单糖 (A)：一种糖核苷酸，其中至少一种单糖 (a) 的至少一个羟基的质子被下述化学式 (1) 至 (5) 中任一个所代表的官能团取代，该单糖选自三糖 (a-1)、四糖 (a-2)、戊糖 (a-3)、己糖 (a-4)、庚糖 (a-5) 和下述单糖 (a-6)。 单糖(a-6)：选自(a-1)、(a-2)、(a-3)、(a-4)和(a-5)组成的组的单糖，其中至少一个选自质子、羟基和羟甲基组成的组的成员被下述取代基(E)取代。 取代基(E)是选自羧基、氨基、N-乙酰氨基、硫酸基、甲基酯、N-甘氨酰、甲基、1,2,3-三羟基丙基、磷酸基和 2-羧基-2-羟乙基组成的组中的至少一个取代基。
• GROUP OF UDP-GLYCOSYLTRANSFERASE FOR CATALYZING CARBOHYDRATE CHAIN ELONGATION AND APPLICATION THEROF
  申请人：SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES

  公开号：US20210163901A1

  公开（公告）日：2021-06-03

  The present invention relates to a group of glycosyltransferase, and an application thereof. Specifically, provided is using glycosyltransferase GT29-32, GT29-33, GT29-34, GT29-4, GT29-5, GT29-7, GT29-9, GT29-11, GT29-13, GT29-17, GT29-18, GT29-19, GT29-20, GT29-21, GT29-22, GT29-23, GT29-24, GT29-25, GT29-36, GT29-37, GT29-42, GT29-43, GT29-45, GT29-46, PNUGT29-1, PNUGT29-2, PNUGT29-3, PNUGT29-4, PNUGT29-5, PNUGT29-6, PNUGT29-7, PNUGT29-8, PNUGT29-9, PNUGT29-14, and PNUGT29-15, as well as derived polypeptides thereof to catalyze the first glycosyl at position C-20, the first glycosyl at position C-6, and the first glycosyl at position C-3 of a tetracyclic triterpene compound substrate to elongate a carbohydrate chain, thereby obtaining a catalytic reaction of ginsenoside products such as ginsenoside Rg3, ginsenoside Rd, ginsenoside Rb1, ginsenoside Rb3, saponin DMGG, saponin DMGX, gypenoside LXXV, gypenoside XVII, gypenoside XIII, gypenoside IX, notoginsenoside U, and notoginsenoside R1, notoginsenoside R2, notoginsenoside R3, 3-O-β-(D-xylopyranosyl)-β-(D-glucopyranosyl)-PPD, 3-O-β-(D-xylopyranosyl)-β-(D-glucopyranosyl)-CK, 20-O-Glucosylginsenoside Rf, and Ginsenoside F3. Glycosyltransferase in the present invention can further be applied to construction of artificially synthesized ginsenoside, novel ginsenoside, and derivatives thereof.
• US9670514B2
  申请人：——

  公开号：US9670514B2

  公开（公告）日：2017-06-06
• [EN] ONE-POT CELL-FREE GLYCOSYLATION PROCESS<br/>[FR] PROCESSUS DE GLYCOSYLATION ACELLULAIRE MONOTOPE
  申请人：C LECTA GMBH

  公开号：WO2022002918A1

  公开（公告）日：2022-01-06

  The invention relates to a process for the preparation of a glycosylated organic compound by in vitro glycosylation of an organic compound having a nucleophilic group with a saccharide under catalysis of a Leloir glycosyltrans-ferase system comprising at least a first glycosyl transferase and a second glycosyl transferase. The invention further relates to a composition comprising a glycosylated organic compound that is obtainable by the process according to the invention.