(2R)-2-[2-[(2S,3R,4R,5S,6R)-3-amino-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropyl-[(2S)-2-aminopropanoyl]amino]pentanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[2-[(2S,3R,4R,5S,6R)-3-amino-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropyl-[(2S)-2-aminopropanoyl]amino]pentanedioic acid
• 化学式: C₁₇H₃₁N₃O₁₀
• 分子量: 437.4
• InChiKey: CIOVSEZPGNAICA-ZUOSKNSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  226
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• Monoclonal antibody against muramyl peptides
  申请人：Agency for Science, Technology and Research

  公开号：US10316079B2

  公开（公告）日：2019-06-11

  Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.

  本发明公开了一种分离抗体或其抗原结合片段，该抗体能够与氨甲酰肽或其衍生物、类似物或盐结合。氨甲酰基肽包括氨甲酰基和选自丙氨酸、异谷氨酰胺、谷氨酸及其盐组成的氨基酸组。还公开了抗体的生产方法、包含抗体的组合物、使用抗体的治疗方法、抗体的用途、检测μramyl肽的方法、检测μramyl肽的检测方法、抗菌剂、杂交瘤和试剂盒。
• EP2909234A1
  申请人：——

  公开号：EP2909234A1

  公开（公告）日：2015-08-26
• MONOCLONAL ANTIBODY AGAINST MURAMYL PEPTIDES IN PREVENTION AND TREATMENT OF IMMUNE-MEDIATED DISEASES
  申请人：Agency for Science, Technology and Research

  公开号：EP3244916A1

  公开（公告）日：2017-11-22
• MONOCLONAL ANTIBODY AGAINST MURAMYL PEPTIDES
  申请人：AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

  公开号：US20150344547A1

  公开（公告）日：2015-12-03

  Disclosed is an isolated antibody or an antigen-binding fragment thereof. The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
• US9695231B2
  申请人：——

  公开号：US9695231B2

  公开（公告）日：2017-07-04