(Furan-2-yl-phenyl-methyl)-((S)-1-phenyl-ethyl)-amine | 478484-18-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (Furan-2-yl-phenyl-methyl)-((S)-1-phenyl-ethyl)-amine
• 英文别名: (1S)-N-[furan-2-yl(phenyl)methyl]-1-phenylethanamine
• CAS: 478484-18-3
• 化学式: C₁₉H₁₉NO
• 分子量: 277.366
• InChiKey: NLPORQVZAKPNHJ-FUKCDUGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Furan-2-yl-phenyl-methyl)-((S)-1-phenyl-ethyl)-amine 在 溴 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 120.0h， 生成 (1S,5R,6S)-6-Benzenesulfonyl-1-phenyl-8-((S)-1-phenyl-ethyl)-8-aza-bicyclo[3.2.1]oct-3-en-2-one
  参考文献：
  名称：

  8-Azabicyclo[3.2.1]oct-3-en-2-ones via asymmetric 1,3-dipolar cycloaddition of a homochiral 3-oxidopyridinium betaine

  摘要：

  8-Azabicyclo[3.2.1]oct-3-en-2-ones were prepared by asymmetric 1,3-dipolar cycloadditions of homochiral pyridinium betaine 4. Excellent diastereofacial selectivity was achieved for the major 6-exo cycloadducts. The absolute stereochemistry of cycloadduct 7 was confirmed by a single-crystal X-ray diffraction study. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.005
• 作为产物：
  描述：

  呋喃甲酰氯 在 titanium(IV) isopropylate 、 palladium diacetate 、 sodium carbonate 作用下， 以 丙酮 为溶剂， 生成 (Furan-2-yl-phenyl-methyl)-((S)-1-phenyl-ethyl)-amine
  参考文献：
  名称：

  8-Azabicyclo[3.2.1]oct-3-en-2-ones via asymmetric 1,3-dipolar cycloaddition of a homochiral 3-oxidopyridinium betaine

  摘要：

  8-Azabicyclo[3.2.1]oct-3-en-2-ones were prepared by asymmetric 1,3-dipolar cycloadditions of homochiral pyridinium betaine 4. Excellent diastereofacial selectivity was achieved for the major 6-exo cycloadducts. The absolute stereochemistry of cycloadduct 7 was confirmed by a single-crystal X-ray diffraction study. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.005

文献信息

• 8-Azabicyclo[3.2.1]oct-3-en-2-ones via asymmetric 1,3-dipolar cycloaddition of a homochiral 3-oxidopyridinium betaine
  作者：Neil R. Curtis、Richard G. Ball、Janusz J. Kulagowski

  DOI：10.1016/j.tetlet.2006.02.005

  日期：2006.4

  8-Azabicyclo[3.2.1]oct-3-en-2-ones were prepared by asymmetric 1,3-dipolar cycloadditions of homochiral pyridinium betaine 4. Excellent diastereofacial selectivity was achieved for the major 6-exo cycloadducts. The absolute stereochemistry of cycloadduct 7 was confirmed by a single-crystal X-ray diffraction study. (c) 2006 Elsevier Ltd. All rights reserved.