Undecyl 3-[2-[(3-methoxy-3-oxopropyl)-(3-oxo-3-undecoxypropyl)amino]propyl-(3-oxo-3-undecoxypropyl)amino]propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Undecyl 3-[2-[(3-methoxy-3-oxopropyl)-(3-oxo-3-undecoxypropyl)amino]propyl-(3-oxo-3-undecoxypropyl)amino]propanoate
• 英文别名: undecyl 3-[2-[(3-methoxy-3-oxopropyl)-(3-oxo-3-undecoxypropyl)amino]propyl-(3-oxo-3-undecoxypropyl)amino]propanoate
• 化学式: C₄₉H₉₄N₂O₈
• 分子量: 839.3
• InChiKey: REFPAVCQASJATM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.2
• 重原子数：
  59
• 可旋转键数：
  49
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20140161830A1

  公开（公告）日：2014-06-12

  Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.
• US9227917B2
  申请人：——

  公开号：US9227917B2

  公开（公告）日：2016-01-05
• US9439968B2
  申请人：——

  公开号：US9439968B2

  公开（公告）日：2016-09-13